3-(5-Oxo-5H-benzo[a]phenoxazin-9-yl)alanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-(5-Oxo-5H-benzo[a]phenoxazin-9-yl)alanine
• 英文别名: 2-amino-3-(5-oxobenzo[a]phenoxazin-9-yl)propanoic acid
• 化学式: C₁₉H₁₄N₂O₄
• 分子量: 334.3
• InChiKey: NZELGSWHCAMWKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR BONE FORMATION AND MODELING
  申请人：ENZO Biochem, Inc.

  公开号：US20130172332A1

  公开（公告）日：2013-07-04

  The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
• US8969339B2
  申请人：——

  公开号：US8969339B2

  公开（公告）日：2015-03-03