(1R)-8-bromo-1-(4-phenylphenyl)-1H-benzo[f]chromene | 1221747-58-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: (1R)-8-bromo-1-(4-phenylphenyl)-1H-benzo[f]chromene
• CAS: 1221747-58-5
• 化学式: C₂₅H₁₇BrO
• 分子量: 413.313
• InChiKey: GNPMHOJUHQVXDN-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-溴-2-萘酚 、 1-([1,1'-biphenyl]-4-yl)prop-2-yn-1-ol 在 氟硼酸铵 、 ((CH3)5C5RuCl(μ2-SC21H19))2 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 48.0h， 生成 (1R)-8-bromo-1-(4-phenylphenyl)-1H-benzo[f]chromene 、
  参考文献：
  名称：

  Ruthenium-Catalyzed Enantioselective [3+3] Cycloaddition of Propargylic Alcohols with 2-Naphthols

  摘要：

  Ruthenium-catalyzed enantioselective [3+3] cycloaddition of propargylic alcohols with 2-naphthols affords the corresponding cycloaddition products in moderate to good yields with a high enantioselectivity (up to 99% ee). This cycloaddition proceeds via stepwise reactions of propargylation and intramolecular cyclization, where ruthenium-allenylidene and -vinylidene complexes work as reactive intermediates, respectively.

  DOI：

  10.1021/om100097k

文献信息

• Ruthenium-Catalyzed Enantioselective [3+3] Cycloaddition of Propargylic Alcohols with 2-Naphthols
  作者：Keiichiro Kanao、Yoshihiro Miyake、Yoshiaki Nishibayashi

  DOI：10.1021/om100097k

  日期：2010.5.10

  Ruthenium-catalyzed enantioselective [3+3] cycloaddition of propargylic alcohols with 2-naphthols affords the corresponding cycloaddition products in moderate to good yields with a high enantioselectivity (up to 99% ee). This cycloaddition proceeds via stepwise reactions of propargylation and intramolecular cyclization, where ruthenium-allenylidene and -vinylidene complexes work as reactive intermediates, respectively.