14-Oxa-2,9,11,13,15,17-hexazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),3,5,7,10,12,15-heptaene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 14-Oxa-2,9,11,13,15,17-hexazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),3,5,7,10,12,15-heptaene
• 英文别名: 14-oxa-2,9,11,13,15,17-hexazatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3,5,7,9,12,15-heptaene
• 化学式: C₁₀H₆N₆O
• 分子量: 226.197
• InChiKey: HISAAWPSSDPBMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  邻苯二胺 、 5,6-二氯-[1,2,5]恶二唑并[3,4-B]吡嗪 以 乙腈 为溶剂， 反应 3.0h， 以93%的产率得到14-Oxa-2,9,11,13,15,17-hexazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),3,5,7,10,12,15-heptaene
  参考文献：
  名称：

  Chemistry of furazano[3,4-b]pyrazine. 4. 5,6-Dichlorofurazano[3,4-b]pyrazine in cyclization reactions

  摘要：

  DOI：

  10.1007/bf02320341

文献信息

• Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents
  申请人：Baures Paul W.

  公开号：US20090131445A1

  公开（公告）日：2009-05-21

  The present invention provides novel compounds of the formula (I) and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.