(3S)-2-aminooctadecane-1,3-diol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3S)-2-aminooctadecane-1,3-diol
• 化学式: C₁₈H₃₉NO₂
• 分子量: 301.5
• InChiKey: OTKJDMGTUTTYMP-ZVAWYAOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Methods of Treating Muscular Wasting Diseases Using NF-kB Activation Inhibitors
  申请人：Guttridge C. Denis

  公开号：US20070225315A1

  公开（公告）日：2007-09-27

  Methods for treating muscular wasting diseases such as Duchenne muscular dystrophy are disclosed. Specifically, the methods include administering to a subject in need of treatment for a muscular wasting disease, an NF-κB activation inhibitor capable of blocking the activation of NF-κB.
• ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210015767A1

  公开（公告）日：2021-01-21

  The invention provides an artificially synthesized single sphingosine lipid and use of delivering a nucleic acid thereof. More particularly, the invention provides Use or method for delivering a nucleic acid to a cell or a subject using a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof, or a combination comprising a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof,
• US8426355B2
  申请人：——

  公开号：US8426355B2

  公开（公告）日：2013-04-23