2-morpholin-4-yl-5-pyrrolidin-1-yl-5H-chromeno[4,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-morpholin-4-yl-5-pyrrolidin-1-yl-5H-chromeno[4,3-d]pyrimidine
• 化学式: C₁₉H₂₂N₄O₂
• 分子量: 338.409
• InChiKey: LMAOUUVQFQUAOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  50.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吗啉-4-羧酰胺 在 sodium ethanolate 、 四氯化钛 作用下， 以 乙醇 、 苯甲醚 、 甲苯 为溶剂， 反应 9.0h， 生成 2-morpholin-4-yl-5-pyrrolidin-1-yl-5H-chromeno[4,3-d]pyrimidine
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity

  摘要：

  A series of new 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines 3a-i have been synthesized and tested in vivo for the anti-inflammatory/analgesic/antipyretic effects and in vitro to evaluate the antiplatelet activity on guinea-pig platelet-rich plasma aggregated by collagen, adenosine-5'-diphosphate (ADP) and arachidonic acid (AA). Title compounds were ineffective in vivo; however, the pyrrolidino derivatives 3a and 3c exhibited an antiplatelet activity against all the aggregants differing from that of acetylsalicylic acid (ASA) while the 5-morpholino derivatives 3g-i showed the most potent ASA-like antiplatelet activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00221-9

文献信息

• Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity
  作者：O Bruno、C Brullo、A Ranise、S Schenone、F Bondavalli、E Barocelli、V Ballabeni、M Chiavarini、M Tognolini、M Impicciatore

  DOI：10.1016/s0960-894x(01)00221-9

  日期：2001.6

  A series of new 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines 3a-i have been synthesized and tested in vivo for the anti-inflammatory/analgesic/antipyretic effects and in vitro to evaluate the antiplatelet activity on guinea-pig platelet-rich plasma aggregated by collagen, adenosine-5'-diphosphate (ADP) and arachidonic acid (AA). Title compounds were ineffective in vivo; however, the pyrrolidino derivatives 3a and 3c exhibited an antiplatelet activity against all the aggregants differing from that of acetylsalicylic acid (ASA) while the 5-morpholino derivatives 3g-i showed the most potent ASA-like antiplatelet activity. (C) 2001 Elsevier Science Ltd. All rights reserved.