7,8-Dihydronaphthalen-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7,8-Dihydronaphthalen-1-amine
• 化学式: C₁₀H₁₁N
• mdl: MFCD19211838
• 分子量: 145.204
• InChiKey: AKAQTNFQSKMGQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  十二/十四烷基二甲基氧化胺 、 7,8-Dihydronaphthalen-1-amine 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 (3aR,9bR)-2-methyl-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-6-amine
  参考文献：
  名称：

  De, Biswanath; DeBernardis, John F.; Prasad, Rajnandan, Synthetic Communications, 1988, vol. 18, # 5, p. 481 - 486

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氨基-3,4-二氢-2H-1-萘酮 在 盐酸 、 sodium tetrahydroborate 作用下， 生成 7,8-Dihydronaphthalen-1-amine
  参考文献：
  名称：

  De, Biswanath; DeBernardis, John F.; Prasad, Rajnandan, Synthetic Communications, 1988, vol. 18, # 5, p. 481 - 486

  摘要：

  DOI：

文献信息

• ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3637489A1

  公开（公告）日：2020-04-15

  An organometallic compound including a transition metal and at least one organic ligand, wherein the organometallic compound satisfies predetermined conditions described in the specification.

  一种包括过渡金属和至少一种有机配体的有机金属化合物，其中有机金属化合物满足说明书中所述的预定条件。
• DE, BISWANATH;DEBERNARDIS, JOHN F.;PRASAD, RAJNANDAN, SYNTH. COMMUN., 18,(1988) N 5, 481-485
  作者：DE, BISWANATH、DEBERNARDIS, JOHN F.、PRASAD, RAJNANDAN

  DOI：——

  日期：——
• MELANIN CONCENTRATING HORMONE ANTAGONIST
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1218336A2

  公开（公告）日：2002-07-03
• HETEROARYLS AND USES THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3094325B1

  公开（公告）日：2021-10-13
• [EN] MELANIN CONCENTRATING HORMONE ANTAGONIST<br/>[FR] ANTAGONISTE DE L'HORMONE DE CONCENTRATION DE LA MELANINE
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2001021577A2

  公开（公告）日：2001-03-29

  A melanin-concentrating hormone antagonist which comprises a compound of formula (I) wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R?1 and R2¿ are independently hydrogen atom or a hydrocarbon group which may have substituents; R?1 and R2¿, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.