Hydroxy-(2-hydroxyphenyl)methanesulfonic acid | 4430-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Hydroxy-(2-hydroxyphenyl)methanesulfonic acid
• CAS: 4430-28-8
• 化学式: C₇H₈O₅S
• 分子量: 204.2
• InChiKey: TXQWCMAOGBSBCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS
  申请人：Brieden Walter

  公开号：US20120316350A1

  公开（公告）日：2012-12-13

  A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (1a), (1b): wherein R 1 is C 6-20 -aryl or C 4-12 -heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, R 2 is C 1-4 -alkyl or C 6-20 -aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, and wherein R 3 is selected from the group consisting of C 1-18 -alkyl, C 6-20 -cycloalkyl, C 6-20 -aryl and C 7-20 -aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R 1 , R 2 and R 3 are as defined above, and b) asymmetrically hydrogenating.

  一种制备式(1a)、(1b)的N-单取代β-氨基醇磺酸盐的方法，其中R1为C6-20芳基或C4-12杂芳基，每个芳基可选择性地被一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基取代，R2为C1-4烷基或C6-20芳基，每个芳基可选择性地被一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基取代，而R3从C1-18烷基、C6-20环烷基、C6-20芳基和C7-20芳基烷基残基中选择；包括a)在压力高于1.5巴的条件下，选择性地在有机溶剂中反应甲基酮、一级胺、甲醛和磺酸，所述有机溶剂可包括水，从而提供式(II)的N-单取代β-氨基酮磺酸盐：其中R1、R2和R3如上所定义；b)不对称氢化。
• Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols
  申请人：Brieden Walter

  公开号：US20090156833A1

  公开（公告）日：2009-06-18

  A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R 1 is C 6-20 -aryl or C 4-12 -heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, R 2 is C 1-4 -alkyl or C 6-20 -aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups and wherein R 3 is selected from the group consisting of C 1-18 -alkyl, C 6-20 -cycloalkyl, C 6-20 -aryl and C 7-20 -aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R 1 , R 2 and R 3 are as defined above, and (b) asymmetrically hydrogenating. The sulfonates in the presence of a base and a catalyst of a transition metal and a disphosphine ligand, in a polar solvent, optionally in the presence of water.

  一种制备公式（Ia），（Ib）的N-单取代β-氨基醇磺酸盐的方法：其中R1是C6-20芳基或C4-12杂芳基，每个选项可用一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基置换，R2是C1-4烷基或C6-20芳基，每个芳基可用一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基置换，其中R3选自由C1-18烷基，C6-20环烷基，C6-20芳基和C7-20芳基烷基残基组成的群。该过程的步骤为：（a）在压力大于1.5巴的情况下，将甲基酮，一级胺，甲醛和磺酸反应，可选地在有机溶剂中，所述有机溶剂可选地包含水，以得到公式（II）的N-单取代β-氨基酮磺酸盐：其中R1，R2和R3如上所述，以及（b）在极性溶剂中，在碱和过渡金属和双膦配体的催化剂存在下，可选地在水的存在下，对磺酸盐进行不对称氢化。
• [DE] SULFINSÄUREDERIVATE UND DEREN HERSTELLUNG UND VERWENDUNG<br/>[EN] SULPHINIC ACID DERIVATIVES, METHOD FOR PRODUCING THEM, AND THEIR USE<br/>[FR] DERIVES D'ACIDE SULFINIQUE, LEUR PRODUCTION ET LEUR UTILISATION
  申请人：L. BRÜGGEMANN KG

  公开号：WO1999018067A1

  公开（公告）日：1999-04-15

  (DE) Die vorliegende Erfindung betrifft Sulfinsäureverbindungen der Formel (I), worin die Substituenten die in der Beschreibung angegebenen Bedeutungen besitzen. Die erfindungsgemäßen Sulfinsäureverbindungen sind als Reduktionsmittel brauchbar, welche keinen Formaldehyd abspalten.(EN) The invention relates to sulphinic acid derivatives of formula (I) wherein the substituents have the meanings given in the Description. The inventive sulphinic acid compounds can be used as reducing agents which do not release formaldehyde.(FR) La présente invention concerne des composés d'acide sulfinique correspondant à la formule (I) dans laquelle les substituants correspondent à la définition donnée dans la description. Les composés d'acide sulfinique selon l'invention peuvent être utilisés comme agents de réduction ne libérant pas de formaldéhyde.

  所述发明涉及硫化酸类化合物，其化学式为(I)，所述化合物中的取代基具有所述描述中所给的意义。所述发明所得到的硫化酸化合物可用于不需要放出甲醛的还原剂。
• SULFINSÄUREDERIVATE UND DEREN HERSTELLUNG UND VERWENDUNG
  申请人：L. Brüggemann KG

  公开号：EP0956282A1

  公开（公告）日：1999-11-17
• Mineral Wool Fiber Mats, Method for Producing Same, and Use
  申请人：Deller Christoph

  公开号：US20130095719A1

  公开（公告）日：2013-04-18

  The invention relates to mineral wool fiber mats, which are stabilized by means of a binder made of polymers funtionalized with epoxy groups and/or with carboxyl groups and selected cross-linking agents. Said mats can be used as an insulating material and are characterized by low or no formaldehyde emissions.