4-isobutyl-piperazine-1-carboxylic acid ethyl ester | 99993-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-isobutyl-piperazine-1-carboxylic acid ethyl ester
• 英文别名: 4-Isobutyl-piperazin-1-carbonsaeure-aethylester；Ethyl 4-(2-methylpropyl)piperazine-1-carboxylate
• CAS: 99993-98-3
• 化学式: C₁₁H₂₂N₂O₂
• mdl: MFCD16308886
• 分子量: 214.308
• InChiKey: PXXJTRJIVVMKDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-哌嗪甲酸乙酯 在 异丁醇 、 邻甲苯磺酸异丁酯 、 sodium carbonate 作用下， 生成 4-isobutyl-piperazine-1-carboxylic acid ethyl ester
  参考文献：
  名称：

  实验性丝虫病化学疗法；制备哌嗪的衍生物。

  摘要：

  DOI：

  10.1021/jo01159a018

文献信息

• IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20220127260A1

  公开（公告）日：2022-04-28

  The present disclosure provides compounds of Formula (I′) (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, cocrystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).
• BENZOTHIAZOLE DERIVATIVES AND 7-AZA-BENZOTHIAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
  申请人：Gray Nathanael S.

  公开号：US20220127284A1

  公开（公告）日：2022-04-28

  The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).
• US7468371B2
  申请人：——

  公开号：US7468371B2

  公开（公告）日：2008-12-23
• EXPERIMENTAL CHEMOTHERAPY OF FILARIASIS. IV. THE PREPARATION OF DERIVATIVES OF PIPERAZINE¹
  作者：H. W. STEWART、R. J. TURNER、J. J. DENTON、S. KUSHNER、L. M. BRANCONE、W. L. McEWEN、R. I. HEWITT、Y. SUBBAROW

  DOI：10.1021/jo01159a018

  日期：1948.1