(2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
• 化学式: C₂₇H₄₄O₇
• 分子量: 480.6
• InChiKey: NKDFYOWSKOHCCO-KCJGERRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  138
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Chemical compounds and use thereof for improving muscular quality
  申请人：BIOPHYTIS

  公开号：US10316056B2

  公开（公告）日：2019-06-11

  Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.

  化合物及其治疗用途，特别是用于改善哺乳动物的肌肉质量。更具体地说，一种改善肌肉疏松哺乳动物肌肉质量的方法，以及使用该化合物治疗和/或预防肌肉疏松症的方法，特别是肌肉疏松性肥胖症及其相关并发症和/或病症，如力量、肌肉质量、表现和体能及运动能力的丧失。此外，还包括一种改善肥胖哺乳动物肌肉质量的方法，以及使用该化合物治疗和/或预防肥胖症及相关并发症和/或病症，尤其是 2 型糖尿病和代谢综合征。
• EP2995310A1
  申请人：——

  公开号：EP2995310A1

  公开（公告）日：2016-03-16
• Compositions for the treatment of overtraining syndrome
  申请人：SHI Research & Development AB

  公开号：EP2995310B1

  公开（公告）日：2021-11-03
• COMPOSITIONS FOR THE TREATMENT OF OVERTRAINING SYNDROME
  申请人：SWEDISH HERBAL INSTITUTE RESEARCH & DEVELOPMENT AB

  公开号：US20170252389A1

  公开（公告）日：2017-09-07

  The invention is directed to compositions for the prophylaxis, treatment and recovery of overtraining syndrome. Compositions comprising a combination of parts of plants or plant extracts belonging to Crassulaceae, Araliaceae and Schisandraceae for the prophylaxis and treatment of overtraining syndrome. In a preferred embodiment the composition further comprises parts of plants or plant extracts of Asteraceae and or pantothenic acid or salts thereof.
• USE OF 20-HYDROXYECDYSONE AND THE DERIVATIVES THEREOF IN THE TREATMENT OF MYOPATHIES
  申请人：BIOPHYTIS

  公开号：US20200179407A1

  公开（公告）日：2020-06-11

  The invention relates to 20-hydroxyecdysone and the derivatives thereof, for use in the treatment of genetic myopathies.