(5R,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-5,6,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (5R,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-5,6,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.4
• InChiKey: JTFNKLILWILVJO-QJISAEMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Treatment screening methods
  申请人：Frincke M. James

  公开号：US20060073099A1

  公开（公告）日：2006-04-06

  The invention includes a method to identify a method to enhance survival of a subject that has been exposed to a biological insult such as an ionizing radiation dose of LD 50/30 by treating the exposed subject with a test compound an optically comparing the results to that obtained using control subjects that had been treated with 3β,17β-dihydroxyandrost-5-ene or other disclosed compounds.

  本发明包括一种方法，用于确定如何提高受到生物损伤的受试者的存活率，如电离辐射剂量为 LD 50/30 用试验化合物处理受试者，并将结果与用 3β,17β-二羟基雄甾-5-烯或其他已公开化合物处理的对照受试者的结果进行光学比较。
• STEROID ANALOGS AND CHARACTERIZATION AND TREATMENT METHODS
  申请人：Hollis-Eden Pharmaceuticals Inc.

  公开号：EP1807118A2

  公开（公告）日：2007-07-18
• Steroid analogs and characterization and treatment methods
  申请人：Reading L. Christopher

  公开号：US20070014719A1

  公开（公告）日：2007-01-18

  The invention relates to methods to characterize exemplified compounds such as 3β, 17β-dihydroxyandrost-1,5,11 -triene and 3β, 17β-dihydroxy-17α-ethynylandrost-1,5,11-triene and to the use of described compounds to ameliorate or treat a condition such as thrombocytopenia, inflammation or other exemplified conditions.
• Drug product and process for making
  申请人：Frincke M. James

  公开号：US20070053832A1

  公开（公告）日：2007-03-08

  The invention provides a drug product for treating radiation exposure comprising, a drug in a dosage form; and packaging for the drug together with a package insert or label that includes information about the drug's efficacy, where the information about the drug's efficacy is obtained at least in part from methods described in the disclosure.
• Surrogate markers
  申请人：Garsd Armando

  公开号：US20070077203A1

  公开（公告）日：2007-04-05

  The invention provides a method to analyze an effect of a biological insult such as exposure to ionizing radiation comprising (a) exposing one or more groups of subjects to a biological insult of at least about an LD 10 to obtain one or more groups of exposed subjects; and (b) measuring one, two, three or more surrogate markers in one or more of the groups of exposed subjects, wherein one, two, three or more of the surrogate markers correlate with death at a P≦0.1.