5'-Methylthio-ImmH

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 5'-Methylthio-ImmH
• 英文别名: 7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(methylsulfanylmethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
• 化学式: C₁₂H₁₆N₄O₃S
• 分子量: 296.35
• InChiKey: CEGIKIXYDFDYDN-RXDXJJGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• METHODS, ASSAYS AND COMPOUNDS FOR TREATING BACTERIAL INFECTIONS BY INHIBITING METHYLTHIOINOSINE PHOSPHORYLASE
  申请人：Schramm Vern L.

  公开号：US20130274220A1

  公开（公告）日：2013-10-17

  The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5′-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.
• US9290501B2
  申请人：——

  公开号：US9290501B2

  公开（公告）日：2016-03-22
• [EN] METHODS, ASSAYS AND COMPOUNDS FOR TREATING BACTERIAL INFECTIONS BY INHIBITING METHYLTHIOINOSINE PHOSPHORYLASE<br/>[FR] PROCÉDÉS, ESSAIS ET COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES PAR L'INHIBITION DE LA MÉTHYLTHIOINOSINE PHOSPHORYLASE
  申请人：EINSTEIN COLL MED

  公开号：WO2012074912A1

  公开（公告）日：2012-06-07

  The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5'- methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.