(6R)-6-[(3,4,5-trimethoxy-N-methylanilino)methyl]-5,6,7,8-tetrahydroquinazoline-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (6R)-6-[(3,4,5-trimethoxy-N-methylanilino)methyl]-5,6,7,8-tetrahydroquinazoline-2,4-diamine
• 化学式: C₁₉H₂₇N₅O₃
• 分子量: 373.4
• InChiKey: LKRXQZIHVMYTOZ-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• ANTIFOLATE COMPOUNDS FOR THE TREATMENT OF MELANOMA
  申请人：Universidad de Murcia

  公开号：EP2231151B1

  公开（公告）日：2013-08-28
• DIHYDROFOLATE REDUCTASE INHIBITION BY EPIGALLOCATECHIN GALLATE COMPOUNDS
  申请人：Rodriguez-Lopez Neptuno Jose

  公开号：US20070249545A1

  公开（公告）日：2007-10-25

  This invention relates to the identification, production and use of Dihydrofolate Reductase (DHFR) inhibitors based on the green tea catechin Epigallocatechin Gallate (EGCG). These inhibitors are, for example, useful in therapy, in particular for the treatment of cancer, infection and inflammatory conditions.
• US9060997B2
  申请人：——

  公开号：US9060997B2

  公开（公告）日：2015-06-23
• [EN] DIHYDROFOLATE REDUCTASE INHIBITION BY EPIGALLOCATECHIN GALLATE COMPOUNDS<br/>[FR] INHIBITION DE LA DIHYDROFOLATE REDUCTASE PAR DES COMPOSES D'EPIGALLOCATECHINE GALLATE
  申请人：UNIV MURCIA

  公开号：WO2006021888A2

  公开（公告）日：2006-03-02

  This invention relates to the identification, production and use of Dihydrofolate Reductase (DHFR) inhibitors based on the green tea catechin Epigallocatechin Gallate (EGCG). These inhibitors are, for example, useful in therapy, in particular for the treatment of cancer, infection and inflammatory conditions.