6-[2-(3H-1,3-benzothiazol-2-ylidene)-5-[(E)-2-phenylethenyl]-1H-tetrazol-2-ium-3-yl]phthalazine-1,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-[2-(3H-1,3-benzothiazol-2-ylidene)-5-[(E)-2-phenylethenyl]-1H-tetrazol-2-ium-3-yl]phthalazine-1,4-dione
• 化学式: C24H16N7O2S+
• 分子量: 466.5
• InChiKey: BEIGFKLRGRRJJA-JLHYYAGUSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHOD AND DEVICE FOR THE DETECTION OF SULPHUR CONTAINING SPECIES
  申请人：Fallis Ian

  公开号：US20130224873A1

  公开（公告）日：2013-08-29

  A method is provided for detecting sulphur-containing species (such as thiophosphorous esters, in particular phosphorylating agents), in which a suspected sulphur-containing species is brought into contact with a tetrazolium compound in the presence of base, typically at a pH of at least 8. A device, kit and tetrazolium compounds for use in such a method are also disclosed.

  提供了一种用于检测含硫物质（如噻磷酯酯，特别是磷酰化剂）的方法，其中将疑似含硫物质与四唑化合物在碱的存在下接触，通常在至少为8的pH下。还公开了用于此类方法的装置、工具包和四唑化合物。
• Diagnostics based on tetrazolium compounds
  申请人：LIFESCAN, INC.

  公开号：EP0990705A1

  公开（公告）日：2000-04-05

  A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises dehydrogenase enzyme that has specificity for the analyte, NAD or an NAD derivative, a tetrazolium dye precursor, a diaphorase enzyme or an analog thereof, and a nitrite salt. The reagent causes dye formation that is a measure of the analyte concentration. The nitrite salt suppresses interfering dye formation caused non-enzymatically by the hemoglobin. Preferably, the reagent is used in a dry strip for measuring ketone bodies, such as beta-hydroxybutyrate.

  一种试剂适用于测量含血红蛋白生物液体（如全血）中分析物的浓度。试剂包括对分析物具有特异性的脱氢酶、NAD 或 NAD 衍生物、四唑染料前体、二磷酸盐酶或其类似物以及亚硝酸盐。试剂会导致染料形成，从而测量被分析物的浓度。亚硝酸盐可抑制血红蛋白非酶促地形成干扰染料。该试剂最好用于测量酮体（如β-羟基丁酸）的干条中。
• Stabilized tetrazolium-phenazine reagent compositions and methods for using the same
  申请人：Lifescan, Inc.

  公开号：EP1312921A1

  公开（公告）日：2003-05-21

  Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a tetrazolium dye component, e.g., a water soluble tetrazolium salt; (2) a phenazine component; and (3) an effective amount of one or more tetrazolium dye-phenazine stabilizing reagents, e.g., an inorganic Group IIIA compound and/or a flavin. In many embodiments, the subject reagent compositions include additional members of an analyte oxidizing signal producing system, such as: an analyte oxidizing enzyme, e.g., an analyte dehydrogenase or an analyte oxidase; and an enzyme cofactor. Also provided are test strips that include the subject reagent compositions, as well as systems and kits incorporating the subject test strips. The subject reagent compositions, test strips, systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof, or ISF (interstitial fluid).

  本发明提供了稳定四氮唑染料-吩嗪试剂组合物及其用于测量样品中分析物的方法。试剂组合物包括(1)四唑鎓染料成分，例如水溶性四唑鎓盐；(2)酚嗪成分；和(3)有效量的一种或多种四唑鎓染料-酚嗪稳定试剂，例如无机 IIIA 族化合物和/或黄素。在许多实施方案中，所述试剂组合物包括分析物氧化信号产生系统的其他成员，例如：分析物氧化酶，如分析物脱氢酶或分析物氧化酶；以及酶辅助因子。此外，还提供了包括主题试剂组合物的试纸，以及包含主题试纸的系统和试剂盒。这些试剂组合物、试纸条、系统和试剂盒可用于检测样品中的各种分析物，如生理样品，如血液或其一部分，或间质液（ISF）。
• Stabilized tetrazolium phenazine reagent compositions and methods for using the same
  申请人：——

  公开号：US20030096389A1

  公开（公告）日：2003-05-22

  Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a tetrazolium dye component, e.g., a water soluble tetrazolium salt; (2) a phenazine component; and (3) an effective amount of one or more tetrazolium dye-phenazine stabilizing reagents, e.g., an inorganic Group IIIA compound and/or a flavin. In many embodiments, the subject reagent compositions include additional members of an analyte oxidizing signal producing system, such as: an analyte oxidizing enzyme, e.g., an analyte dehydrogenase or an analyte oxidase; and an enzyme cofactor. Also provided are test strips that include the subject reagent compositions, as well as systems and kits incorporating the subject test strips. The subject reagent compositions, test strips, systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof, or ISF (interstitial fluid).

  本发明提供了稳定四氮唑染料-吩嗪试剂组合物及其用于测量样品中分析物的方法。试剂组合物包括(1)四唑鎓染料成分，例如水溶性四唑鎓盐；(2)酚嗪成分；和(3)有效量的一种或多种四唑鎓染料-酚嗪稳定试剂，例如无机 IIIA 族化合物和/或黄素。在许多实施方案中，所述试剂组合物包括分析物氧化信号产生系统的其他成员，例如：分析物氧化酶，如分析物脱氢酶或分析物氧化酶；以及酶辅助因子。此外，还提供了包括主题试剂组合物的试纸，以及包含主题试纸的系统和试剂盒。这些试剂组合物、试纸条、系统和试剂盒可用于检测样品中的各种分析物，如生理样品，如血液或其一部分，或间质液（ISF）。
• Stabilized tetrazolium reagent compositions and methods for using the same
  申请人：——

  公开号：US20030096332A1

  公开（公告）日：2003-05-22

  Stabilized tetrazolium dye reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include a tetrazolium dye component, e.g., a water soluble tetrazolium salt, and an effective amount of a nitrite stabilizing agent, e.g., a nitrite salt. In many embodiments, the subject reagent compositions include additional members of an analyte oxidizing signal producing system, such as: an analyte oxidizing enzyme, e.g., an analyte dehydrogenase or an analyte oxidase; an electron transfer agent; and an enzyme cofactor. Also provided are test strips that include the subject reagent compositions, as well as systems and kits incorporating the subject test strips. The subject reagent compositions, test strips, systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof, or ISF (interstitial fluid).

  本发明提供了稳定的四唑鎓染料试剂组合物及其用于测量样品中分析物的方法。所述试剂组合物包括四唑染料成分，例如水溶性四唑盐，以及有效量的亚硝酸盐稳定剂，例如亚硝酸盐。在许多实施方案中，所述试剂组合物包括分析物氧化信号产生系统的其他成员，例如：分析物氧化酶，如分析物脱氢酶或分析物氧化酶；电子传递剂；以及酶辅助因子。此外，还提供了包括主题试剂组合物的试纸，以及包含主题试纸的系统和试剂盒。这些试剂组合物、试纸条、系统和试剂盒可用于检测样品中的各种分析物，如生理样品，如血液或其一部分，或间质液（ISF）。