5-{[(2S)-2-methylpiperazin-1-yl]sulfonyl}isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-{[(2S)-2-methylpiperazin-1-yl]sulfonyl}isoquinoline
• 英文别名: 5-[(2S)-2-methylpiperazin-1-yl]sulfonylisoquinoline
• 化学式: C₁₄H₁₇N₃O₂S
• 分子量: 291.37
• InChiKey: BDVFVCGFMNCYPV-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ALISKIREN MODULATION OF NEUROGENESIS
  申请人：Barlow Carrolee

  公开号：US20090197823A1

  公开（公告）日：2009-08-06

  The disclosure provides compositions and methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of a renin inhibitor in combination with one or more neurogenic agents. The disclosure also includes compositions and methods for stimulating or activating the formation of new nerve cells based on the application of a renin inhibitor in combination with one or more neurogenic agents.
• [EN] ALISKIREN MODULATION OF NEUROGENESIS<br/>[FR] MODULATION DE LA NEUROGENÈSE AVEC L'ALISKIREN
  申请人：BRAINCELLS INC

  公开号：WO2010111136A2

  公开（公告）日：2010-09-30

  The disclosure provides compositions and methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of a renin inhibitor in combination with one or more neurogenic agents. The disclosure also includes compositions and methods for stimulating or activating the formation of new nerve cells based on the application of a renin inhibitor in combination with one or more neurogenic agents.