Methoxyisobutylisonitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methoxyisobutylisonitrile
• 英文别名: 1-isocyano-1-methoxy-2-methylpropane
• 化学式: C6H11NO
• 分子量: 113.16
• InChiKey: CEYVKTKJMLCDGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  13.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20150374858A1

  公开（公告）日：2015-12-31

  Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.

  披露了来自非甾体抗炎药（NSAIDs）的衍生物及其使用方法，这对于识别和定位患者疼痛感觉的病理和/或炎症部位；识别原发、继发、良性或恶性肿瘤的部位；以及诊断感染或确认或排除疑似感染非常有用。基于NSAID的偶联物含有成像基团。这些偶联物在环氧化酶表达增加的部位富集，从而揭示了前列腺素产生增加的部位，这与疼痛和炎症有关，并与肿瘤存在和/或位置有关。识别COX表达增加的区域也有助于筛查感染。
• Transition metal conjugated radiopharmaceuticals useful as therapeutic and/or diagnostic agents
  申请人：Universitat Autònoma De Barcelona

  公开号：EP2426107A1

  公开（公告）日：2012-03-07

  It is provided new compounds, succinimidyl ester of the Zn(II) dithiocarbamate of isonipecotic acid and succinimidyl ester of the Zn(II) dithiocarbamate of nipecotic acid; their preparation processes by reacting any salt of the above compounds with TSTU; conjugated compounds of the above ones, and their preparation processes comprising reacting the succinimidyl ester of the Zn(II) dithiocarbamate of isonipecotic acid or the succinimidyl ester of the Zn(II) dithiocarbamate of nipecotic acid with a molecule which comprises at least a primary and/or secondary amine; and transition metal conjugated compounds, and their preparation processes comprising a transmetallation reaction between the conjugated succinimidyl ester of the Zn(II) dithiocarbamate of isonipecotic acid or the succinimidyl ester of the Zn(II) dithiocarbamate of nipecotic acid with [M(CO)3(H2O)3]X wherein M is a transition metal; and X is a halide anion. The invention further provides the use of the transition metal conjugated compounds as therapeutic and/or diagnostic agents.

  提供了新的化合物，分别是异哌啶酸锌（II）二硫代氨基甲酸酯和烟酰异哌啶酸锌（II）二硫代氨基甲酸酯；它们的制备方法是通过将上述化合物的任何盐与TSTU反应；上述化合物的共轭化合物，以及它们的制备方法包括将异哌啶酸锌（II）二硫代氨基甲酸酯的烟酰异哌啶酸酯或烟酰异哌啶酸锌（II）二硫代氨基甲酸酯与至少含有一种主要和/或次要胺基的分子反应；以及过渡金属共轭化合物，其制备方法包括将共轭的异哌啶酸锌（II）二硫代氨基甲酸酯的烟酰异哌啶酸酯或烟酰异哌啶酸锌（II）二硫代氨基甲酸酯与[M(CO)3(H2O)3]X之间进行过渡金属反应，其中M是过渡金属；X是卤素阴离子。该发明还提供了将过渡金属共轭化合物用作治疗和/或诊断剂的用途。
• TECHNETIUM-99m COMPLEX AS A TOOL FOR THE IN VIVO DIAGNOSIS OF CANCEROUS TUMOURS
  申请人：Guminski Yves

  公开号：US20130171067A1

  公开（公告）日：2013-07-04

  The invention relates to a compound having formula (I), compositions containing same and preparation methods thereof. The invention also relates to a complex of the compound having formula (I) with technetium-99m and tricine, the use of this complex as a diagnostic probe, diagnostic compositions containing same and methods for preparing the complex and compositions containing same.

  该发明涉及具有化学式（I）的化合物，含有该化合物的组合物以及其制备方法。该发明还涉及具有化学式（I）的化合物与锝-99m和三甘氨酸的复合物，该复合物作为诊断探针的用途，含有相同化合物的诊断组合物以及制备该复合物和含有相同化合物的组合物的方法。
• MOLECULAR IMAGING AGENTS
  申请人：MISHANI Eyal

  公开号：US20110293519A1

  公开（公告）日：2011-12-01

  Provided is radiolabeled ammonium salts and uses thereof as myocardial perfusion agents in molecular imaging.

  提供了放射标记的铵盐及其在分子影像中作为心肌灌注剂的用途。
• [EN] TUMOUR RADIOLABELLING IMAGING AGENTS COMPRISING ORNITHINE AND DERIVATIVES THEREOF<br/>[FR] AGENTS D'IMAGERIE POUR LE RADIOMARQUAGE DES TUMEURS COMPRENANT DE L'ORNITHINE ET SES DÉRIVÉS
  申请人：SINGAPORE HEALTH SERV PTE LTD

  公开号：WO2011133115A1

  公开（公告）日：2011-10-27

  The present invention relates to a radiolabelling imaging agent comprising ornithine and derivatives thereof modified to incorporate a Technetium (99n,Tc) radiolabel. The radioiabelled imaging agents are substrates for Ornithine Decarboxylase (ODC) and can be used for imaging of cancers in which ODC expression is upregulated.

  本发明涉及一种放射性标记成像剂，包括鸟氨酸及其衍生物，经过修饰以包含钚（99n，Tc）放射性标记。这些放射性标记的成像剂是鸟氨酸脱羧酶（ODC）的基质，可用于成像ODC表达上调的癌症。