7-(3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-(3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 英文别名: 7-(3-Amino-4-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid；7-(3-amino-4-methylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 化学式: C₁₇H₁₉FN₄O₃
• 分子量: 346.361
• InChiKey: IUEUWLKCMNXFEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  Ethyl 7-(3-acetamido-4-methylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate 生成 7-(3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  MATSUMOTO, DZYUNITI;MIYAMOTO, AKIYUKI;UNO, DZYUN;NAKAMURA, SINITI

  摘要：

  DOI：

文献信息

• Novel 1,8-Naphthyridine derivatives, and process for preparation thereof
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：EP0132845A2

  公开（公告）日：1985-02-13

  The present invention relates to a 1,8-naphthyridine derivative of the formula wherein R1, R2 and R3 are the same or different and each hydrogen or lower alkyl having 1 to 5 carbon atoms; and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents.

  本发明涉及一种 1,8-萘啶衍生物，其式中 R1、R2 和 R3 是相同或不同的，每个都是氢或具有 1 至 5 个碳原子的低级烷基；以及其酯和盐及其制备方法。 这些化合物显示出优异的抗菌活性，是有用的抗菌剂。
• SUSTAINED-RELEASE ORAL OINTMENT
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP0788801A1

  公开（公告）日：1997-08-13

  The preent invention relates to a sustained-release oral ointment which comprises a hydrophobic ointment base, an adhesive substance, an aluminum compound and a drug. The ointment is useful as a sustained-release oral ointment which has applicability to an oral mucosa, particularly to a peridontal pocket, sustained-release properties to supply a drug to affected part over a long period of time while maintaining the concentration thereof at a sufficiently high level, and enhanced ratio of utilization of drug (the ratio of the total amount of drug released to affected part to the total amount of drug in the ointment applied).

  本发明涉及一种缓释口服软膏，它由疏水性软膏基质、粘合物质、铝化合物和药物组成。该软膏可作为一种缓释口腔软膏，适用于口腔粘膜，特别是牙周袋；具有缓释特性，可在将药物浓度保持在足够高的水平的同时，长期向患部提供药物；并可提高药物利用率（释放到患部的药物总量与软膏中药物总量之比）。
• JPS60260577A
  申请人：——

  公开号：JPS60260577A

  公开（公告）日：1985-12-23
• US4649144A
  申请人：——

  公开号：US4649144A

  公开（公告）日：1987-03-10
• US5858408A
  申请人：——

  公开号：US5858408A

  公开（公告）日：1999-01-12