DB377

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: DB377
• 英文别名: 2,5-bis(4-O-ethoxyamidinophenyl)furan；N'-ethoxy-4-[5-[4-[(Z)-N'-ethoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide
• 化学式: C₂₂H₂₄N₄O₃
• 分子量: 392.458
• InChiKey: ONCFTTNZEWQYPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 羟胺 作用下， 生成 DB377
  参考文献：
  名称：

  Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs

  摘要：

  We report the synthesis of 2,5-bis-[4-amidinophenyl]furan bis-amidoxime(2), the corresponding bis-O-methylamidoxime(3) and the corresponding bis-O-ethylamidoxime(4) and their evaluation as prodrugs against Pneumocystis carinii pneumonia. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00557-4

文献信息

• Process for the synthesis of bis-aryl diamidoxime compounds
  申请人：University of North Carolina at Chapel Hill

  公开号：US20040127721A1

  公开（公告）日：2004-07-01

  Bis-aryl diamidoxime compounds, such as 2,5-bis[4-hydroxy and 4-O-alkylamidinophenyl]furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis[4-hydroxy and 4-O-alkylamidinophenyl]furans, are useful as therapeutic compounds. The disclosed process is scalable, simpler, more economic and more feasible than other presently known methods of preparing 2,5-bis[4-hydroxy and 4-O-alkylamidinophenyl]furans and other bis-aryl diamidoxime compounds.

  双取代芳基二肝素化合物，例如2,5-双[4-羟基和4-O-烷基酰胺基苯基]呋喃，可以通过一步钯催化交叉反应从2,5-双三烷基锡烷制备。双取代芳基二肝素化合物，例如2,5-双[4-羟基和4-O-烷基酰胺基苯基]呋喃，可用作治疗化合物。所披露的方法比现有的其他制备2,5-双[4-羟基和4-O-烷基酰胺基苯基]呋喃和其他双取代芳基二肝素化合物的方法更具可扩展性、更简单、更经济和更可行。
• Anbazhagan, Mariappan; Boykin, David W., Heterocyclic Communications, 2003, vol. 9, # 2, p. 117 - 118
  作者：Anbazhagan, Mariappan、Boykin, David W.

  DOI：——

  日期：——
• PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1565457A2

  公开（公告）日：2005-08-24
• US7071338B2
  申请人：——

  公开号：US7071338B2

  公开（公告）日：2006-07-04
• [EN] PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS<br/>[FR] PROCEDE DE SYNTHESE DE COMPOSES BIS-ARYL DIAMIDOXIME
  申请人：UNIV NORTH CAROLINA

  公开号：WO2004051217A2

  公开（公告）日：2004-06-17

  Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-0-alkylamidinophenyl] furans, are useful as therapeutic compounds. The disclosed process is scalable, simpler, more economic and more feasible than other presently known methods of preparing 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans and other bis-aryl diamidoxime compounds.