8-Fluoro-2,4-dimethylindolo[2,1-b]quinazoline-6,12-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-Fluoro-2,4-dimethylindolo[2,1-b]quinazoline-6,12-dione
• 化学式: C₁₇H₁₁FN₂O₂
• 分子量: 294.28
• InChiKey: WGQNOVHKRYKTET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION
  申请人：VALIANTE Nicholas M.

  公开号：US20120244182A1

  公开（公告）日：2012-09-27

  The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.

  本发明提供了免疫刺激组合物及其给药方法。还提供了一种给予吲哚丹宁化合物有效量的方法，以增强受体对抗原的免疫反应。还提供了一种给予有效量的吲哚丹宁化合物的方法，以刺激受体对癌症的免疫反应。此外，还提供了将吲哚丹宁化合物作为免疫治疗剂治疗传染病的方法。
• US5441955A
  申请人：——

  公开号：US5441955A

  公开（公告）日：1995-08-15
• US8012987B2
  申请人：——

  公开号：US8012987B2

  公开（公告）日：2011-09-06
• US8193185B2
  申请人：——

  公开号：US8193185B2

  公开（公告）日：2012-06-05
• [EN] INDOLO[2,1-b]QUINAZOLINE-6,12-DIONE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSES ANTIBACTERIENS INDOLO[2,1-B]QUINAZOLINE-6,12-DIONE ET PROCEDES D'UTILISATION DESDITS COMPOSES
  申请人：PATHOGENESIS CORPORATION

  公开号：WO1995013807A1

  公开（公告）日：1995-05-26

  (EN) Methods, compounds and compositions are provided from inhibiting the growth of pathogenic mycobacteria $i(in vitro) and of treatment of pathogenic mycobacterial infections $i(in vivo) using indolo[2,1-b]quinazoline-6,12-dione compounds of formula (I), wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, and the pharmaceutically acceptable salts thereof. The methods, compounds and compositions are particularly useful for inhibiting the growth of $i(Mycobacterium tuberculosis), and may be used alone, or in combination with other anti-$i(Mycobacterium tuberculosis) agents, such as isoniazid, rifampin, pyrazinamide, rifabutin, streptomycin and ciprofloxacin, to provide new agents for the treatment of tuberculosis, including multidrug-resistant tuberculosis (MDRTB).(FR) Procédés, composés et compositions destinés à inhiber la croissance de mycobactéries pathogènes $i(in vitro) et à traiter des infections dues audites mycobactéries pathogènes $i(in vivo) à l'aide de composés indolo[2,1-b]quinazoline-6,12-dione de formule (I), dans laquelle A, B, C, D, E, F, G et H sont indépendamment choisis parmi carbone et azote, ou bien A et B ou C et D peuvent être ensemble azote ou soufre, et sels pharmaceutiquement acceptables desdits composés. Lesdits procédés, composés et compositions sont particulièrement utiles pour inhiber la croissance de $i(Mycobacterium tuberculosis) et peuvent être utilisés seuls ou en combinaison avec d'autres agents de lutte contre $i(Mycobacterium tuberculosis), tels qu'isoniazide, rifampine, pyrazinamide, rifabutine, streptomycine et ciproflaxine, de manière à obtenir de nouveaux agents pour le traitement de la tuberculose, y compris la tuberculose à résistance multiple aux médicaments.