Hexanedioic acid bis-thiazol-2-ylamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Hexanedioic acid bis-thiazol-2-ylamide
• 英文别名: N,N'-di(thiazol-2-yl)hexanediamide；N,N'-bis(1,3-thiazol-2-yl)hexanediamide
• 化学式: C₁₂H₁₄N₄O₂S₂
• 分子量: 310.401
• InChiKey: LRTZYXGHWWJXLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基噻唑 、 己二酰氯 生成 Hexanedioic acid bis-thiazol-2-ylamide
  参考文献：
  名称：

  Biological evaluation of hepatitis c virus helicase inhibitors

  摘要：

  A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00263-3

文献信息

• COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS
  申请人：Larsson Pia

  公开号：US20140051716A1

  公开（公告）日：2014-02-20

  There is provided a compound which is a histone deacetylase (HDAC) inhibitor, or a pharmaceutically acceptable ester, amide, solvate or salt thereof, for use in: (I) treating or preventing a pathological condition associated with excess fibrin deposition and/or thrombus formation; and/or (II) potentiating the degradation of fibrin deposits and preventing such deposits associated with pathological conditions or which may lead to such conditions, wherein the HDAC inhibitor, and the dose thereof, is as described in the description. There is also provided valproic acid, or a pharmaceutically acceptable salt thereof, for use in improving or normalizing endogenous fibrinolysis impaired by local or systemic inflammation.
• Biological evaluation of hepatitis c virus helicase inhibitors
  作者：Chee Wee Phoon、Poh Yong Ng、Anthony E Ting、Su Ling Yeo、Mui Mui Sim

  DOI：10.1016/s0960-894x(01)00263-3

  日期：2001.7

  A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described. (C) 2001 Elsevier Science Ltd. All rights reserved.