6,7-diethoxy-1-(3,4-diethoxy-benzyl)-3-methyl-isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6,7-diethoxy-1-(3,4-diethoxy-benzyl)-3-methyl-isoquinoline
• 英文别名: 6,7-Diaethoxy-1-(3,4-diaethoxy-benzyl)-3-methyl-isochinolin；1-[(3,4-Diethoxyphenyl)methyl]-6,7-diethoxy-3-methylisoquinoline
• 化学式: C₂₅H₃₁NO₄
• 分子量: 409.525
• InChiKey: GOUWNTCDQAECHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,7-diethoxy-1-(3,4-diethoxy-benzyl)-3-methyl-isoquinoline 、 碘甲烷 以 甲醇 、 氯仿 为溶剂， 生成 1-(3,4-Diethoxy-benzyl)-6,7-diethoxy-2,3-dimethyl-isoquinolinium; iodide
  参考文献：
  名称：

  简单的异喹啉和苄基异喹啉生物碱可作为潜在的抗菌剂，抗疟疾剂，细胞毒性剂和抗HIV剂。

  摘要：

  测试了26种简单异喹啉和21种苄基异喹啉的抗微生物，抗疟疾，细胞毒性和抗HIV活性。一些简单的异喹啉生物碱在每种测定法中均具有显着活性，并且可用作开发潜在化学治疗剂的先导化合物。这些化合物包括13（抗微生物），25、26和42（抗动物），13和25（细胞毒性）以及28和29（抗HIV）。异喹啉或二氢异喹啉鎓类型的季氮原子可能有助于提高前三种活性的效力。相反，发现四氢异喹啉盐和6,7-二羟基异喹啉盐具有抗HIV活性。

  DOI：

  10.1016/s0968-0896(01)00154-7
• 作为产物：
  描述：

  (3,4-diethoxy-phenyl)-acetic acid-[2-(3,4-diethoxy-phenyl)-1-methyl-ethylamide] 生成 6,7-diethoxy-1-(3,4-diethoxy-benzyl)-3-methyl-isoquinoline
  参考文献：
  名称：

  Papaverine Homologs. III. The Preparation of Some 3-Methylisoquinolines¹

  摘要：

  DOI：

  10.1021/ja01138a051

文献信息

• Bruckner et al., Journal of the Chemical Society, 1948, p. 885,889
  作者：Bruckner et al.

  DOI：——

  日期：——
• The price of peace: the personal and financial cost of paramilitary punishments in Northern Ireland
  作者：P.C Nolan、J McPherson、R McKeown、H Diaz、D Wilson

  DOI：10.1016/s0020-1383(99)00197-7

  日期：2000.1

  The aim of this study was to compare the injuries sustained during paramilitary punishments both before and after the onset of "peace" in Northern Ireland. A retrospective chart review was performed looking at age, injuries, treatments instituted, theatre time, length of hospital stay and overall cost of care. In the 10-month period before the ceasefire, 31 patients were treated after sustaining paramilitary punishment shootings. Mean age was 25.2 years. All patients had small entrance and exit wounds with minimal soft tissue disruption. A total of 18 fractures were recorded in 15 patients and 14 arteries required repair. Mean operative time was 2.6 h, mean hospital stay 7.61 days and mean cost per patient pound 3102. In the following 10-month period 28 patients were admitted after punishments, only one of whom had been shot, all others had been beaten with sticks and clubs. Mean age was 27.4 years. In 52 limbs, 64 fractures were recorded and 44% of these were open; 15 of the fractures were Gustilo and Anderson Grade III or greater and 11 of the fractures were intra-articular. There were no arterial injuries. Mean operative time was 2.6 h, mean hospital stay 12.4 h and mean cost per patient pound 3849. (C) 2000 Elsevier Science Ltd. All rights reserved.