5,7-Dimethyl-6-(4-trifluoromethylphenyl)naphthalene-2,3-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5,7-Dimethyl-6-(4-trifluoromethylphenyl)naphthalene-2,3-diol
• 英文别名: 5,7-dimethyl-6-[4-(trifluoromethyl)phenyl]naphthalene-2,3-diol
• 化学式: C₁₉H₁₅F₃O₂
• 分子量: 332.322
• InChiKey: IOAHBGWMDCRODI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯丙酮 、 1-(4-(三氟甲基)苯基)丙烷-2-酮 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 5,7-Dimethyl-6-(4-trifluoromethylphenyl)naphthalene-2,3-diol
  参考文献：
  名称：

  Synthesis and hiv-1 integrase inhibitory activities of catechol and bis-Catechol derivatives

  摘要：

  Fourteen catechol and bis-catechol derivatives have been synthesised and tested for their HIV-1 inhibitory activities. The six more active molecules have been tested for their antiviral activity and cytotoxicity. We have found that bis-catechols 1 and 2 are the most active HIV-1 integrase inhibitor whereas the best antiviral compound is 4. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00658-8

文献信息

• Synthesis and hiv-1 integrase inhibitory activities of catechol and bis-Catechol derivatives
  作者：Romain Dupont、Laurence Jeanson、Jean-François Mouscadet、Philippe Cotelle

  DOI：10.1016/s0960-894x(01)00658-8

  日期：2001.12

  Fourteen catechol and bis-catechol derivatives have been synthesised and tested for their HIV-1 inhibitory activities. The six more active molecules have been tested for their antiviral activity and cytotoxicity. We have found that bis-catechols 1 and 2 are the most active HIV-1 integrase inhibitor whereas the best antiviral compound is 4. (C) 2001 Elsevier Science Ltd. All rights reserved.