(E)-3-([1,3,4]Thiadiazol-2-ylcarbamoyl)-acrylic acid | 91270-55-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-3-([1,3,4]Thiadiazol-2-ylcarbamoyl)-acrylic acid
• 英文别名: 4-Oxo-4-((1,3,4-thiadiazol-2-yl)amino)-2-butenoic acid；(E)-4-oxo-4-(1,3,4-thiadiazol-2-ylamino)but-2-enoic acid
• CAS: 91270-55-2
• 化学式: C₆H₅N₃O₃S
• 分子量: 199.19
• InChiKey: MNUAOWSWXIGCNE-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-3-([1,3,4]Thiadiazol-2-ylcarbamoyl)-acrylic acid 在 sodium disulfite 作用下， 以 水 、 异丙醇 为溶剂， 生成 Sodium; 1-carboxy-2-([1,3,4]thiadiazol-2-ylcarbamoyl)-ethanesulfonate
  参考文献：
  名称：

  Production of surface-active agents with pronounced pharmacological activity

  摘要：

  DOI：

  10.1007/bf00767101

文献信息

• KABACHNYJ, V. I.;CHERNYX, V. P.;KABACHNYJ, G. I.;SOPELNIK, E. M., XIM.-FARMATS. ZH., 1985, 19, N 1, 43-46
  作者：KABACHNYJ, V. I.、CHERNYX, V. P.、KABACHNYJ, G. I.、SOPELNIK, E. M.

  DOI：——

  日期：——
• INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF
  申请人：HSF Pharmaceuticals

  公开号：EP3512602A2

  公开（公告）日：2019-07-24
• Inhibitors of heat shock factors and uses thereof
  申请人：Vilaboa Nuria

  公开号：US20210221778A1

  公开（公告）日：2021-07-22

  The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
• [EN] INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF<br/>[FR] INHIBITEURS DU FACTEUR DE CHOC THERMIQUE ET UTILISATIONS DE CEUX-CI
  申请人：HSF PHARMACEUTICALS

  公开号：WO2018050656A2

  公开（公告）日：2018-03-22

  The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
• Production of surface-active agents with pronounced pharmacological activity
  作者：V. I. Kabachnyi、V. P. Chernykh、G. I. Kabachnyi、E. M. Sopel'nik

  DOI：10.1007/bf00767101

  日期：1985.1