Cholesteryl phosphoryl choline | 65956-64-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cholesteryl phosphoryl choline
• 英文别名: 2-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• CAS: 65956-64-1
• 化学式: C32H59NO4P+
• 分子量: 552.8
• InChiKey: MWEZHNCHKXEIBJ-UHFFFAOYSA-O

物化性质

• 熔点：
  286-288 °C

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3

文献信息

• Novel alkyl phospholipid derivatives and uses thereof
  申请人：Zentaris GmbH

  公开号：EP1800684A1

  公开（公告）日：2007-06-27

  The present invention provides novel alkyl phospholipid derivatives that are useful for treating various diseases including tumors and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular fungi, protozoa, bacteria and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies, in particular for the treatment of leishmaniasis, trypanosomiasis and/or malaria.

  本发明提供了新型烷基磷脂衍生物，可用于治疗包括肿瘤和/或哺乳动物（尤其是人类）中由微生物，特别是真菌、原虫、细菌和/或病毒引起的各种疾病，这些烷基磷脂可作为单一药物或结合疗法的一部分，特别是用于治疗利什曼病、锥虫病和/或疟疾。
• NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
  申请人：PERRISSOUD Daniel

  公开号：US20070167408A1

  公开（公告）日：2007-07-19

  The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.
• [EN] NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF<br/>[FR] NOUVEAUX DERIVES D'ALKYLPHOSPHOLIPIDE AYANT UNE CYTOTOXICITE REDUITE ET UTILISATIONS DE CEUX-CI
  申请人：ZENTARIS GMBH

  公开号：WO2007071658A2

  公开（公告）日：2007-06-28

  [EN] The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.
  [FR] La présente invention concerne de nouveaux dérivés d'alkylphospholipide ayant une cytotoxicité réduite qui sont utiles pour traiter différentes maladies et/ou états pathophysiologiques chez des mammifères, de préférence des humains, qui sont causés par des micro-organismes, en particulier des bactéries, des champignons, des protozoaires et/ou des virus. De tels alkylphospholipides peuvent être utilisés en tant que médicaments uniques ou dans le cadre de polythérapies et peuvent également être utilisés pour le traitement de tumeurs.