1-[3-[[(3R,7R,9S,10S,12S,13R,14S,17R)-17-[(1R)-4-[benzyl(methyl)amino]-1-methyl-butyl]-3,7-bis(3-guanidinopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl]oxy]propyl]guanidine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1-[3-[[(3R,7R,9S,10S,12S,13R,14S,17R)-17-[(1R)-4-[benzyl(methyl)amino]-1-methyl-butyl]-3,7-bis(3-guanidinopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl]oxy]propyl]guanidine
• 英文别名: 2-[3-[[(3R,7R,9S,10S,12S,13R,14S,17R)-17-[(2R)-5-[benzyl(methyl)amino]pentan-2-yl]-3,7-bis[3-(diaminomethylideneamino)propoxy]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl]oxy]propyl]guanidine
• 化学式: C₄₄H₇₈N₁₀O₃
• 分子量: 795.2
• InChiKey: QRDHQYSRNBZTEQ-PVZTUBLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  57
• 可旋转键数：
  22
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  224
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• MEDICAL DEVICES INCORPORATING CERAGENIN-CONTAINING COMPOSITES
  申请人：Savage Paul B.

  公开号：US20130245760A1

  公开（公告）日：2013-09-19

  A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 Ξm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
• INCORPORATION OF PARTICULATE CERAGENINS IN POLYMERS
  申请人：Savage Paul B.

  公开号：US20130243840A1

  公开（公告）日：2013-09-19

  A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 μm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
• US8932614B2
  申请人：——

  公开号：US8932614B2

  公开（公告）日：2015-01-13
• US8945217B2
  申请人：——

  公开号：US8945217B2

  公开（公告）日：2015-02-03