(4R)-4-[(3R,7R,9S,10S,12S,13R,14S,17R)-3,7,12-tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentan-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (4R)-4-[(3R,7R,9S,10S,12S,13R,14S,17R)-3,7,12-tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentan-1-ol
• 化学式: C₃₃H₆₃N₃O₄
• 分子量: 565.9
• InChiKey: KJHKUNPRTTYLNC-RNIIZGTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  40
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• MEDICAL DEVICES INCORPORATING CERAGENIN-CONTAINING COMPOSITES
  申请人：Savage Paul B.

  公开号：US20130245760A1

  公开（公告）日：2013-09-19

  A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 Ξm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
• INCORPORATION OF PARTICULATE CERAGENINS IN POLYMERS
  申请人：Savage Paul B.

  公开号：US20130243840A1

  公开（公告）日：2013-09-19

  A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 μm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
• Oral Care Compositions
  申请人：Vazquez Joe

  公开号：US20140369941A1

  公开（公告）日：2014-12-18

  Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.
• ORAL CARE COMPOSITIONS
  申请人：Vazquez Joe

  公开号：US20140363780A1

  公开（公告）日：2014-12-11

  Described herein are aqueous and substantially non-aqueous oral compositions comprising a cationic steroidal compound and methods of making and using the same.
• ORAL CARE COMPOSITIONS AND METHODS OF USE
  申请人：Vazquez Joe

  公开号：US20160045421A1

  公开（公告）日：2016-02-18

  Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.