(2-Azaniumylcyclohexyl)azanium;dichloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-Azaniumylcyclohexyl)azanium;dichloride
• 化学式: C6H16Cl2N2
• 分子量: 187.11
• InChiKey: HEKOZXSZLOBKGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• [EN] SYNTHESIS OF CYCLIC CARBONATES<br/>[FR] SYNTHÈSE DE CARBONATES CYCLIQUES
  申请人：UNIV NEWCASTLE

  公开号：WO2009109765A1

  公开（公告）日：2009-09-11

  A dimeric aluminium(salen) catalyst of formula I: herein: Y-Q is CRC1=N or CRC1RC2-NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nitro; each of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16, is independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, ether and nitro; X1 and X2 are independently either (i) a C2-5 alkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl, or a C1-3 bisoxyalkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl or (ii) represent a divalent group selected from C5-7 arylene, C5-7 cyclic alkylene and C3-7 heterocyclylene, which may be optionally substituted; (i) (a) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is selected from L-A, where L is a single bond or a C1-10 alkylene group and A is an ammonium group paired with a counterion selected from Cl, Br and I; and/or (b) at least one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A, where Q is either -C(=O)-O-, -C(=O)-NH-, or a single bond; and/or (ii) (a) one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is L-A', where L is as defined above and A' is a ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (b) one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A'.

  一种二聚铝（salen）催化剂的化学式I：在此处：Y-Q是CRC1=N或CRC1RC2-NRN1，其中RC1、RC2和RN1分别独立选择自H、卤素、可选择性取代的C1-20烷基、可选择性取代的C5-20芳基、醚和硝基；R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16中的每一个取代基都是独立选择自H、卤素、可选择性取代的C1-20烷基、可选择性取代的C5-20芳基、可选择性取代的C3-20杂环烷基、醚和硝基；X1和X2独立地是（i）C2-5烷基链，可选择性地通过一个或多个来自C1-4烷基和C5-7芳基的基团取代，或者是C1-3双氧烷基链，可选择性地通过一个或多个来自C1-4烷基和C5-7芳基的基团取代；或者（ii）代表可选择性取代的C5-7芳基、C5-7环烷基和C3-7杂环烷基中选取的二价基团；（i）（a）R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16中至少一个选择自L-A，其中L是单键或C1-10烷基基团，A是与Cl、Br和I中选取的对离子配对的铵基；和/或（b）X1和X2中至少一个是含有一个环原子为季氮原子的三价C3-7杂环烷基团，配对的对离子为Cl、Br和I；和/或（c）X1和X2中至少一个是由基团-Q-L-A取代的C2-5烷基链或C1-3双氧烷基链，其中Q是-E(=O)-O-、-E(=O)-NH-或单键；和/或（ii）（a）R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16中的一个是L-A'，其中L如上所定义，A'是与Cl、Br和I中选取的对离子配对的铵基固定在固体支撑上；或者（b）X1和X2中的一个是含有一个环原子为季氮原子构成铵基固定在固体支撑上的三价C3-7杂环烷基团，配对的对离子为Cl、Br和I；或者（c）X1和X2中的一个是由基团-Q-L-A'取代的C2-5烷基链或C1-3双氧烷基链。
• Optically pure cis-oxalato(trans-l-1,2-cyclohexanediamine)Pt(II) and process for resolving optical isomers of a platinum complex compound
  申请人：Tanaka Kikinzoku Kogyo K.K.

  公开号：EP0567438A1

  公开（公告）日：1993-10-27

  A process of optically resolving an optically active platinum complex compound consisting of a mixture of a d-isomer and an I-isomer uses high performance liquid chromatography employing a column packed with a chiral filler. The chiral filler may be, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester andβ-and-γ-cyclodextrin. An optically pure cis-oxalato (trans-1-1,2-cyclohexanediamine) Pt(II) separated from a d-isomer by the process of the invention is found to be remarkably effective as a raw material for preparing a carcinostatic agent. Complete optical purity of the compound reflects in a lower melting point of the substance as compared with that of an impure substance.

  一种光学解析由 d-异构体和 I-异构体混合物组成的具有光学活性的铂络合物的工艺，采用了高效液相色谱法，在色谱柱中填充了手性填料。 例如，手性填料可以是纤维素酯衍生物、氨基甲酸纤维素衍生物、氨基甲酸淀粉衍生物、聚甲基丙烯酸酯和β-和γ-环糊精。 通过本发明的工艺从 d-异构体中分离出的光学纯顺式草酸（反式-1-1,2-环己二胺）铂(II)，作为制备致癌剂的原料效果显著。 该化合物的完全光学纯度反映了该物质的熔点低于不纯物质的熔点。
• ANTIMALARIAL QUINOLIN DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0876346A1

  公开（公告）日：1998-11-11
• BACKBONE-SUBSTITUTED BIFUNCTIONAL DOTA LIGANDS, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING SAME
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1545498A2

  公开（公告）日：2005-06-29
• EP1545498A4
  申请人：——

  公开号：EP1545498A4

  公开（公告）日：2006-09-06