1-Pentanamine, N-pentyl-N-propyl

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Pentanamine, N-pentyl-N-propyl
• 英文别名: N-pentyl-N-propylpentan-1-amine
• 化学式: C₁₃H₂₉N
• 分子量: 199.38
• InChiKey: DQCCZIHHKAGIHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Quaternary ammonium compounds
  申请人：——

  公开号：US20030158176A1

  公开（公告）日：2003-08-21

  Novel quaternary ammonium compounds of the formula 1 and any stereoisomers thereof, wherein R 1 , R 2 and R 3 independently represent C 1 -C 6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R 1 , R 2 and R 3 may form a ring together with the quaternary ammonium nitrogen; R 4 represents —H, —CH 3 , or —CO—R 4-1 ,wherein R 4-1 represents —(C 1 -C 4 alkyl), —(C 1 -C 4 alkoxy), or —NR 4-2 R 4-3 , wherein R 4-2 and R 4-3 independently represent —H or —(C 1 -C 4 alkyl); R 5 , R 6 and R 7 independently represent —H, —OCH 3 , —OH, —CONH 2 , —SO 2 NH 2 , —F, —Cl, —Br, —I, —CF 3 , or —(C 1 -C 4 alkyl), optionally substituted with one or two —OH, —(C 1 -C 4 alkoxy), —COOH, or —CO—O—(C 1 -C 3 alkyl); and X − represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

  新颖的四元铵化合物的化学式为1，及其所有立体异构体，其中R1、R2和R3分别表示C1-C6烷基，可选择地取代为苯基或羟基，或两者兼有，且其中任意两个R1、R2和R3可与四元铵氮形成环；R4表示—H，—CH3，或—CO—R4-1，其中R4-1表示—(C1-C4烷基)，—(C1-C4烷氧基)，或—NR4-2R4-3，其中R4-2和R4-3独立地表示—H或—(C1-C4烷基)；R5、R6和R7独立地表示—H，—OCH3，—OH，—CONH2，—SO2NH2，—F，—Cl，—Br，—I，—CF3，或—(C1-C4烷基)，可选择地取代为一个或两个—OH，—(C1-C4烷氧基)，—COOH，或—CO—O—(C1-C3烷基)；X-表示药学上可接受的酸的阴离子，这些化合物用作药物，用这些化合物制造特定药物的用途，以及包含这些化合物的药物组合物。本发明还涉及涉及给药的治疗方法。
• [EN] PREPARATION PROCESS OF FESOTERODINE AND INTERMEDIATES<br/>[FR] MÉTHODE DE PRÉPARATION DE FESOTÉRODINE ET D'INTERMÉDIAIRES
  申请人：PANACEA BIOTEC LTD

  公开号：WO2011158257A1

  公开（公告）日：2011-12-22

  The present invention relates to a process of synthesis of 3,3 dipheylpropylamines, which may be used as pharmaceutical intermediates in the preparation of their pharmacologically active derivatives such as fesoterodine, tolterodine, their enantiomers, pharmaceutically acceptable salts and related compounds useful as antimuscarinic agents.

  本发明涉及一种合成3,3-二苯基丙胺的方法，可用作药物中间体，用于制备其药理活性衍生物，如非索罗定、托特罗定、它们的对映体、药用可接受的盐和相关化合物，这些化合物可用作抗胆碱能药物。
• [EN] HALOGEN SUBSTITUTED 3,3-DIPHENYLPROPYLAMINES (TOLTERODINE) HAVING ANTIMUSCARINIC ACTIVITY<br/>[FR] 3,3-DIPHENYLPROPYLAMINES (TOLTERODINE) A SUBSTITUTION HALOGENE AYANT UNE ACTIVITE ANTIMUSCARINIQUE
  申请人：UPJOHN CO

  公开号：WO2004096751A1

  公开（公告）日：2004-11-11

  Novel 3,3-diphenylpropylamines of the formula OR, and any stereoisomers thereof; wherein R1 represents -H or -CH3; R2 represents -CX3r -CR2_1X2r -CR2_1R2_2X, or -CR2_1R2_2H, wherein X represents halogen, and R2_1 and R2_2 independently represent -H or -(C1-C4 alkyl), optionally substituted with halogen; R3 and R4 independently represent -H, -OCH3r -OH, - CONH2r -SO2NH2, -F, -Cl, -Br, -I, -CF3, or - (C1-C4 alkyl) , optionally substituted with one or two -OH, -(C1-C4 alkoxy), -COOH, or -CO-O- (C1-C3 alkyl) ; and R5 and R6 independently represent C1-C6 alkyl, optionally substituted with hydroxyl, wherein R5 and R6 together contain at least three carbon at­oms, and wherein R5 and R6 may form a ring together with the amine nitrogen; provided that R2 comprises at least one halogen; or a physiologically acceptable acid addition salt thereof; the 3,3-diphenylpropylamines for use as medica­ments, use of the 3,3-diphenylpropylamines for the manufac­ture of specific medicaments, and pharmaceutical composi­tions comprising the 3,3-diphenylpropylamines. The present invention also includes a method of treatment involving ad­ ministration of the 3,3-diphenylpropylamines.

  3,3-二苯基丙基胺的化学式为OR的小说，以及其任何立体异构体；其中R1代表-H或-CH3；R2代表-CX3r -CR2_1X2r -CR2_1R2_2X，或-CR2_1R2_2H，其中X代表卤素，而R2_1和R2_2独立地代表-H或-(C1-C4烷基)，可选地用卤素取代；R3和R4独立地代表-H，-OCH3r -OH，-CONH2r -SO2NH2，-F，-Cl，-Br，-I，-CF3，或-(C1-C4烷基)，可选地用一个或两个-OH，-(C1-C4烷氧基)，-COOH，或-CO-O-(C1-C3烷基)取代；而R5和R6独立地代表C1-C6烷基，可选地用羟基取代，其中R5和R6一起含有至少三个碳原子，并且R5和R6可以与胺氮一起形成环；前提是R2至少包含一个卤素；或其生理上可接受的酸盐；3,3-二苯基丙基胺用作药物，3,3-二苯基丙基胺用于制造特定药物的用途，以及含有3,3-二苯基丙基胺的药物组合物。本发明还包括涉及3,3-二苯基丙基胺给药的治疗方法。
• Method for producing 3,3-diarylpropylamines
  申请人：——

  公开号：US20040034080A1

  公开（公告）日：2004-02-19

  The invention relates to a novel method for producing 3,3-diarylpropylamines of formula (I), wherein A represents a substituted or unsubstituted aryl radical, X represents H, OH or OR 3 and Y, R 1 , R 2 and R 3 have the meanings given in the description, by hydroformylation/hydrocarbonylation and subsequent reductive amination using a transition metal catalyst. 1

  本发明涉及一种新的方法，用氢甲酰化/氢羰基化和过渡金属催化剂进行还原胺化反应，制备式（I）的3,3-二芳基丙基胺，其中A代表取代或未取代的芳基基团，X代表H，OH或OR3，而Y，R1，R2和R3的含义如描述中所给。1
• [EN] 3,3-DIARYLPROPYLAMINE DERIVATIVES AND PROCESSES FOR ISOLATION THEREOF<br/>[FR] DERIVES DE 3,3-DIARYLPROPYLAMINE ET PROCEDES PERMETTANT DE LES ISOLER
  申请人：RANBAXY LAB LTD

  公开号：WO2004078700A1

  公开（公告）日：2004-09-16

  The invention relates to 3,3-diarylpropylamines derivatives and processes for producing them. More particularly, it relates to the preparation of pure tolterodine or a pharmaceutically acceptable salt thereof and pharmaceutical compositions that include the pure tolterodine or a pharmaceutically acceptable salt thereof. It also relates to a novel 3,3­diarylpropylamine derivative, referred to as tolterodine dimer. Chemically, tolterodine dimer is N,N-di-[3-[2-hydroxy-5-methylphenyl]-3-phenylpropyl]isopropylamine and has structural Formula (I), The invention also relates to use of pure tolterodine or tolterodine dimer as reference standards or reference markers for checking the purity of tolterodine.

  本发明涉及3,3-二芳基丙胺衍生物及其制备方法。更具体地说，涉及纯度高的托吡酯或其药学上可接受的盐的制备，以及包括纯托吡酯或其药学上可接受的盐的制药组合物。还涉及一种新型的3,3-二芳基丙胺衍生物，称为托吡酯二聚体。在化学上，托吡酯二聚体是N,N-二-[3-[2-羟基-5-甲基苯基]-3-苯基丙基]异丙胺，其结构式为(I)。本发明还涉及将纯托吡酯或托吡酯二聚体用作参考标准或参考标记物，以检查托吡酯的纯度。