1,3-Pyrimidin-2-one, 4-t-butylcarbonylamino-

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,3-Pyrimidin-2-one, 4-t-butylcarbonylamino-
• 英文别名: 2,2-dimethyl-N-(2-oxo-1H-pyrimidin-6-yl)propanamide
• 化学式: C₉H₁₃N₃O₂
• 分子量: 195.22
• InChiKey: XKRPIYRONQPDFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20150152131A1

  公开（公告）日：2015-06-04

  A compound represented by a formula [1D] as shown below (wherein R 1A , R 1B , R 2A , R 2B , R 3A and R 3B represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  下列的化合物，其化学式为[1D]（其中R1A、R1B、R2A、R2B、R3A和R3B代表氢原子、可选择取代的C1-6烷基等），可作为生产硫代核苷的中间体，本发明的生产方法可作为一种生产硫代核苷的方法。
• SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL) CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20160024132A1

  公开（公告）日：2016-01-28

  A compound represented by a formula [1D] as shown below (wherein R 1A , R 1B , R 2A , R 2B , R 3A and R 3B represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  下列化学式[1D]所代表的化合物(其中R1A、R1B、R2A、R2B、R3A和R3B分别代表氢原子、可选择取代的C1-6烷基等)可用作生产硫代核苷的中间体，而本发明的生产方法则可用作生产硫代核苷的方法。
• Stereoselective glycosylation process
  申请人：ELI LILLY AND COMPANY

  公开号：EP0577303A1

  公开（公告）日：1994-01-05

  A stereoselective glycosylation process for preparing β anomer fluoronucleosides via the SN₂ displacement of an anomeric sulfonyloxy group of an α anomer enriched fluorocarbohydrate with a nucleobase.

  通过 SN₂ 置换富含α异构体的含氟碳水化合物的异构体磺酰氧基与核碱基，制备β异构体含氟核苷的立体选择性糖基化工艺。
• Stereoselective anion glycosylation process
  申请人：ELI LILLY AND COMPANY

  公开号：EP0577304A1

  公开（公告）日：1994-01-05

  A stereoselective anion glycosylation process for preparing β anomer enriched 2'-deoxy-2',2'-difluoronucleosides by reacting an αanomer enriched 2-deoxy-fluoro-1-halo carbohydrate with at least a molar equivalent of a nucleobase salt in an inert solvent.

  一种立体选择性阴离子糖基化工艺，用于制备β异构体富集的 2'-脱氧-2',2'-二氟核苷，其方法是在惰性溶剂中将富集了 α异构体的 2-脱氧-氟-1-卤碳水化合物与至少一个摩尔当量的核碱基盐反应。
• INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES
  申请人：FUJIFILM Corporation

  公开号：EP2883866A1

  公开（公告）日：2015-06-17

  A compound represented by a formula [ID] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  由下式[ID]表示的化合物（其中 R1A、R1B、R2A、R2B、R3A 和 R3B 代表氢原子、任选取代的 C1-6 烷基等）可用作生产硫代核苷的中间体，本发明的生产方法可用作生产硫代核苷的方法。