3-(2-Thienyl)-n-propyl-dimethylamin | 23711-40-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(2-Thienyl)-n-propyl-dimethylamin
• 英文别名: dimethyl-(3-thiophen-2-yl-propyl)-amine；2-Thiophenepropanamine, N,N-dimethyl-；N,N-dimethyl-3-thiophen-2-ylpropan-1-amine
• CAS: 23711-40-2
• 化学式: C₉H₁₅NS
• 分子量: 169.291
• InChiKey: GYVRJKAGZONKTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NITRIC OXIDE RELEASING COMPOUNDS FOR THE TREATMENT OF NEUROPHATIC PAIN<br/>[FR] COMPOSÉS LIBÉRANT DE L'OXYDE NITRIQUE POUR LE TRAITEMENT DE DOULEURS NEUROPHATIQUES
  申请人：NICOX SA

  公开号：WO2011092065A1

  公开（公告）日：2011-08-04

  The present invention relates to nitric oxide releasing derivatives of serotonin norepinephrine reuptake inhibitors and their use for the treatment of pain, having the following general formula (I) or pharmaceutically acceptable salts thereof: wherein : A is selected from the formulas (1a) and (1b). The present invention also relates to pharmaceutical formulation comprising such derivatives, to a process for their preparation and to intermediates useful for their preparation.

  本发明涉及血清素去甲肾上腺素再摄取抑制剂的一氧化氮释放衍生物及其在治疗疼痛中的应用，具有以下一般式(I)或其药学上可接受的盐：其中：A选自式(1a)和(1b)。本发明还涉及包含这种衍生物的药物配方，以及用于它们的制备的过程和有用的中间体。
• [EN] AMINOPROPOXYPHENYL AND BENZYL 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]-1'-YL DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN<br/>[FR] DÉRIVÉS D'AMINOPROPOXYPHÉNYLE ET DE BENZYL 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPÉRIDINE]-1'-YL AYANT UNE ACTIVITÉ MULTIMODALE CONTRE LA DOULEUR
  申请人：ESTEVE PHARMACEUTICALS SA

  公开号：WO2019180189A1

  公开（公告）日：2019-09-26

  The present invention relates to aminopropoxyphenyl and benzyl 3,4-dihydro-2H- spiro[isoquinoline-1,4'-piperidin]-1'-ylderivatives having dual pharmacological activity towards both the α2δ-subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the µ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有对电压门控钙通道的α2δ亚基，特别是α2δ-1亚基，和µ-阿片受体双重药理活性的氨基丙氧基苯基和苄基3,4-二氢-2H-螺[异喹啉-1,4'-哌啶]-1'-醛衍生物，以及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗中的用途，特别是用于疼痛治疗。
• [EN] ORTHO SUBSTITUTED PHENOXYPROPYLAMINO AND BENZYLOXYPROPYLAMINO DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN<br/>[FR] DÉRIVÉS DE PHÉNOXYPROPYLAMINO ET DE BENZYLOXYPROPYLAMINO ORTHO-SUBSTITUÉS PRÉSENTANT UNE ACTIVITÉ MULTIMODALE CONTRE LA DOULEUR
  申请人：ESTEVE PHARMACEUTICALS SA

  公开号：WO2020021021A1

  公开（公告）日：2020-01-30

  The present invention relates to ortho substituted phenoxypropylamino and benzyloxypropylamino derivatives having pharmacological activity towards the α2δ subunit of the voltage-gated calcium channel, in particular to ortho substituted phenoxypropylamino and benzyloxypropylamino derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1 ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及对电压门控钙通道的α2δ亚基具有药理活性的邻位取代苯氧丙基氨基和苄氧丙基氨基衍生物，特别是对同时具有对电压门控钙通道的α2δ亚基和sigma-1（σ1）受体的双重药理活性的邻位取代苯氧丙基氨基和苄氧丙基氨基衍生物，以及制备这些化合物的方法，包括它们的药物组合物和在治疗中的应用，特别是用于治疗疼痛。
• [EN] NOVEL PROCESS FOR PREPARATION OF DULOXETINE AND INTERMEDIATES FOR USE THEREIN<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE DULOXÉTINE ET INTERMÉDIAIRES POUR L'UTILISER
  申请人：ARCH PHARMALABS LTD

  公开号：WO2009109992A1

  公开（公告）日：2009-09-11

  A novel process for the preparation of substantially (S)-(+)-N-methyl-3-(l-naphthalenyloxy)- 3-(2-thiophenyl) propanamine hydrochloride comprising formation of lewis acid salt of (S)- (+)-N-methyl-3-(l-naphthalenyloxy)-3-(2-thiophenyl) propanamine and (S)-(+)-N,N- dimethyl-3-(l-naphthalenyloxy)-3-(2-thiophenyl) propanamine to remove the R isomer of (S)-(+)-N-methyl-3-(l-naphthalenyloxy)-3-(2-thiophenyl) propanamine and (S)-(+)-N,N- dimethyl-3-(l-naphthalenyloxy)-3-(2-thiophenyl) propanamine avoiding removing R isomer impurity without resolution through formation of chiral salt.

  一种制备(S)-(+)-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺盐酸盐的新工艺，包括形成(S)-(+)-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺和(S)-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺的路易斯酸盐，以去除(S)-(+)-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺和(S)-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺的R异构体，避免通过手性盐的形成去除R异构体杂质而不进行分离。
• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：S&T Global Inc.

  公开号：US20130210704A1

  公开（公告）日：2013-08-15

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

  本发明涉及公式(I)的化合物或其药学上可接受的盐，其中符号如规范中所定义；以及包含该化合物的制药组合物，用于治疗或预防病毒感染、炎症、干眼症、中枢神经系统疾病、心血管疾病、癌症、肥胖症、糖尿病、肌肉营养不良和脱发的方法。