Cis-8-thiabicyclo[4.3.0]nonane S,S-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: Cis-8-thiabicyclo[4.3.0]nonane S,S-dioxide
• 英文别名: 1,3,3a,4,5,6,7,7a-octahydro-2-benzothiophene 2,2-dioxide
• 化学式: C₈H₁₄O₂S
• 分子量: 174.26
• InChiKey: VGQCRPHTIKWVRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Anti-bacterial agents based upon oxoanion binding
  申请人：——

  公开号：US20030105062A1

  公开（公告）日：2003-06-05

  Compounds of the structure I: 1 are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T 1 , and T 2 are each independently selected from the group consisting of O, NR, and CH 2 , where R=H or C 1 -C 8 alkyl, or C 1 -C 8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.

  结构式I:1的化合物可用于治疗细菌生长，其中E从B、P和S组中选择，T1和T2各自独立地从O、NR和CH2组中选择，其中R=H或C1-C8烷基或C1-C8氧代烷基，L从乙烯、丙烯和四至六元环和芳香环中选择，前提是结构式I不包括AI-2硼酸盐。这些化合物可用于治疗人类的细菌感染和调节生物膜形成。包含一种或多种此类化合物的药物组合物可用于治疗人类的细菌感染。
• INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR AND APPLICATION
  申请人：Nanjing Transthera Biosciences Co. Ltd.

  公开号：EP3617204A1

  公开（公告）日：2020-03-04

  The present invention belongs to the field of medical technology. Particularly, the present invention relates to a compound shown in formula (I), a pharmaceutically acceptable salt thereof, and a stereoisomer of the same. X, Y, Z, R1, R2, R3, R1a, R2a, m, and n are as defined in the specification. The present invention also relates to pharmaceutical preparations and pharmaceutical compositions of these compounds and a use thereof in preparing a drug for treating a related disease mediated by abnormal indoleamine 2,3-dioxygenase (IDO).

  本发明属于医疗技术领域。特别是，本发明涉及一种式（I）所示的化合物、其药学上可接受的盐及其立体异构体。X、Y、Z、R1、R2、R3、R1a、R2a、m 和 n 如说明书中所定义。本发明还涉及这些化合物的药物制剂和药物组合物及其在制备治疗由异常吲哚胺 2，3-二氧 化酶（IDO）介导的相关疾病的药物中的用途。
• US6737415B2
  申请人：——

  公开号：US6737415B2

  公开（公告）日：2004-05-18
• US7074776B2
  申请人：——

  公开号：US7074776B2

  公开（公告）日：2006-07-11
• US7326695B2
  申请人：——

  公开号：US7326695B2

  公开（公告）日：2008-02-05