Phosphonothioic acid, methyl-, S-(2-diethylaminoethyl) O-cyclopentyl ester | 93240-66-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Phosphonothioic acid, methyl-, S-(2-diethylaminoethyl) O-cyclopentyl ester
• 英文别名: 2-[cyclopentyloxy(methyl)phosphoryl]sulfanyl-N,N-diethylethanamine
• CAS: 93240-66-5
• 化学式: C₁₂H₂₆NO₂PS
• 分子量: 279.38
• InChiKey: PMVOUPZOZITGTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CARBALDEHYDE OXIMES AS BUTYRYLCHOLINESTERASE REACTIVATORS
  申请人：Etat Français représenté par la Direction Centrale Du Service de Santé des Armées

  公开号：EP3945092A1

  公开（公告）日：2022-02-02

  The present invention relates to compounds for their use in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of the intoxication with at least one organophosphorus nerve agent. The invention also relates to pharmaceutical compositions and kits comprising said compounds, and compounds per se.

  本发明涉及化合物，用于重新激活丁酰胆碱酯酶。这些化合物在治疗或预防至少一种有机磷神经毒剂中毒方面是有用的。该发明还涉及包含所述化合物的药物组合物和试剂盒，以及化合物本身。
• Dantrolene prodrugs and methods of their use
  申请人：EAGLE RESEARCH LABS LIMITED

  公开号：US11352347B2

  公开（公告）日：2022-06-07

  The disclosure is directed to dantrolene prodrugs, compositions thereof, and methods of their use in the treatment of disease.

  本公开涉及丹曲林原药、其组合物及其用于治疗疾病的方法。
• METHODS OF USING DANTROLENE TO TREAT NERVE AGENT EXPOSURE
  申请人：Eagle Pharmaceuticals, Inc.

  公开号：EP3678659A1

  公开（公告）日：2020-07-15
• COMPOSITIONS AND METHODS FOR TREATING NERVE AGENT EXPOSURE
  申请人：Hoffman Steven

  公开号：US20200163952A1

  公开（公告）日：2020-05-28

  The present disclosure is directed to transdermal compositions comprising a poison antidote, and methods of using such compositions to counteract the effects of a poison.
• DANTROLENE PRODRUGS AND METHODS OF THEIR USE
  申请人：EAGLE RESEARCH LABS LIMITED

  公开号：US20200239455A1

  公开（公告）日：2020-07-30

  The disclosure is directed to dantrolene prodrugs, compositions thereof, and methods of their use in the treatment of disease.