methyl-bis-(5-methyl-furfuryl)-amine | 109843-37-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methyl-bis-(5-methyl-furfuryl)-amine
• 英文别名: N-Methylbis(5-methylfurfuryl)amine；N-methyl-1-(5-methylfuran-2-yl)-N-[(5-methylfuran-2-yl)methyl]methanamine
• CAS: 109843-37-0
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: SZJFWXKTWAXPGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基呋喃 、 盐酸甲胺 在 聚合甲醛 作用下， 生成 methyl-bis-(5-methyl-furfuryl)-amine
  参考文献：
  名称：

  Tsuboyama; Yanagita, Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1959, vol. 53, p. 318,327

  摘要：

  DOI：

文献信息

• SUBSTITUTED PYRAZINONE DERIVATIVES AS ALPHA2C-ADRENORECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP1966191B1

  公开（公告）日：2010-03-17
• Substituted Pyrazinone Derivatives as Alpha2C-Adrenoreceptor Antagonists
  申请人：Andre-Gil Jose Ignacio

  公开号：US20080269251A1

  公开（公告）日：2008-10-30

  The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1 , having selective α 2C -adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
• Tsuboyama; Yanagita, Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1959, vol. 53, p. 318,327
  作者：Tsuboyama、Yanagita

  DOI：——

  日期：——

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