2,3-Dimethyltetrahydrothiophene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 2,3-Dimethyltetrahydrothiophene
• 英文别名: 2,3-dimethylthiolane
• 化学式: C₆H₁₂S
• 分子量: 116.23
• InChiKey: PQAQKWCWCGKBDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS
  申请人：Cusack Kevin P.

  公开号：US20140179676A1

  公开（公告）日：2014-06-26

  The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

  本发明提供了一种公式(I)的化合物，其中变量如本文所述定义。所述化合物的药用盐、前药、生物活性代谢物、立体异构体和同分异构体。本发明的化合物可用于治疗免疫学和肿瘤学疾病。
• [EN] INHIBITORS OF HEPATITIS C VIRUS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：GILEAD SCIENCES INC

  公开号：WO2014008285A1

  公开（公告）日：2014-01-09

  Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

  化合物I的结构已经披露，以及其药用盐。还披露了使用这些化合物的方法和含有这些化合物的药物组合物。
• SUBSTITUTED PYRAZOLES AS HERBICIDES
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US20150105252A1

  公开（公告）日：2015-04-16

  Disclosed is a method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A, R 1 , Q and J are as defined in the disclosure. Also disclosed is a method wherein the compound of Formula 1 (i.e. in a herbicidally effective amount) is comprised in a herbicidal composition further comprising at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents. Also disclosed are compound of Formula 1 (including all stereoisomers), including N-oxides and salts thereof, their use as herbicides wherein A, R 1 , Q and J are as defined in the disclosure.

  揭示了一种控制不受欢迎植被生长的方法，包括使用化合物Formula 1的草甘膦有效量与植被或其环境接触，其中Formula 1中的所有立体异构体、N-氧化物和盐均包括在内，其中A、R1、Q和J如披露中所定义。还揭示了一种方法，其中Formula 1的化合物（即在草甘膦有效量中）包含在一个杀草剂组合物中，该组合物进一步包括从表面活性剂、固体稀释剂和液体稀释剂组成的群体中选择的至少一种成分。还揭示了Formula 1的化合物（包括所有立体异构体）、包括N-氧化物和盐，其用作除草剂，其中A、R1、Q和J如披露中所定义。
• Inhibitors of Checkpoint Kinases
  申请人：Brnardic Edward J.

  公开号：US20080114016A1

  公开（公告）日：2008-05-15

  The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by ad-ministering the compound to a patient in need of treatment of cancer.

  本发明提供了一种含有融合嘧唑的化合物，可以抑制CHK1活性。本发明还提供了包含这些抑制化合物的组合物以及通过向需要癌症治疗的患者施用该化合物来抑制CHK1活性的方法。
• TRICYCLIC BENZOYLPYRAZOLE DERIVATIVES
  申请人：Witschel Matthias

  公开号：US20070197393A1

  公开（公告）日：2007-08-23

  Tricyclic benzoylpyrazole derivatives of the formula I where: X is oxygen, sulfur, S═O, S(═O) 2 , CR 6 R 7 , NR 8 or a bond; Y together with the two carbons to which it is attached forms a saturated, partially saturated or unsaturated 5- or 6-membered heterocycle; R 1 , R 2 , R 6 , R 7 are hydrogen, alkyl, haloalkyl, alkoxy or haloalkoxy; R 3 is halogen, alkyl, haloalkyl, alkoxy or haloalkoxy; R 4 is hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, unsubstituted or substituted aminosulfonyl or unsubstituted or substituted sulfonylamino; R 5 is hydrogen, alkyl or halogen; l is 0, 1 or 2; R 8 is hydrogen, alkyl, haloalkyl, alkylcarbonyl, formyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylsulfonyl or haloalkylsulfonyl; R 9 is substituted pyrazol-4-ylcarbonyl or substituted 5-oxopyrazolin-4-ylmethylidene; and their agriculturally useful salts; processes and intermediates for preparing the tricyclic benzoylpyrazole derivatives; compositions comprising them and the use of these derivatives or of the compositions comprising them for controlling undesirable plants are described.

  化合物I的三环苯甲酰吡唑衍生物的公式为：其中：X是氧、硫、S═O、S（═O）2、CR6R7、NR8或键；Y与其连接的两个碳原子形成饱和、部分饱和或不饱和的5-或6元杂环；R1、R2、R6、R7为氢、烷基、卤代烷基、烷氧基或卤代烷氧基；R3为卤素、烷基、卤代烷基、烷氧基或卤代烷氧基；R4为氢、硝基、卤素、氰基、烷基、卤代烷基、烷氧基、卤代烷氧基、烷基硫基、卤代烷基硫基、烷基亚磺酰基、卤代烷基亚磺酰基、烷基磺酰基、卤代烷基磺酰基、未取代或取代的氨基磺酰基或未取代或取代的磺酰胺基；R5为氢、烷基或卤素；l为0、1或2；R8为氢、烷基、卤代烷基、烷基羰基、甲酰基、烷氧羰基、卤代烷氧羰基、烷基磺酰基或卤代烷基磺酰基；R9为取代的吡唑-4-基羰基或取代的5-氧代吡唑-4-基甲基亚胺基；以及它们的农业有用盐；描述了制备这些三环苯甲酰吡唑衍生物的过程和中间体；包含它们的组合物以及使用这些衍生物或包含它们的组合物来控制不良植物的用途。