1,4-Dihydro-1-methyl-cinnolin-4-on-3-carbonsaeure | 883-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,4-Dihydro-1-methyl-cinnolin-4-on-3-carbonsaeure
• 英文别名: 1-Methyl-3-carboxy-cinnolon-(4)；1-Methyl-4-cinnolon-3-carbonsaeure；1-methyl-4-oxo-1,4-dihydro-cinnoline-3-carboxylic acid；1-Methyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid；1-methyl-4-oxocinnoline-3-carboxylic acid
• CAS: 883-18-1
• 化学式: C₁₀H₈N₂O₃
• mdl: MFCD18483345
• 分子量: 204.185
• InChiKey: MRKGRJJAAGFLFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0560604A1

  公开（公告）日：1993-09-15

  A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical formulations containing the same for the prevention and/or treatment of various disorders such as nausea and/or emesis caused by anticancer drugs or the X-ray treatment, central nervous disorders such as anxiety and/or neuropathy, gastroenteric diseases such as indigestion, chronic gastritis, digestive ulcer and irritable bowel syndromes, hemicrania cluster headache, trigeminal neuralgia or arrhythmia has the following formula :

  一种对5-羟色胺5-HT3受体具有拮抗活性的新型噌啉衍生物、其药学上可接受的盐、其N-氧化物衍生物或其溶解物，以及含有该衍生物的药物制剂，用于预防和/或治疗各种疾病，如抗癌药物或X射线治疗引起的恶心和/或呕吐、中枢神经疾病，如焦虑和/或神经病变；肠胃疾病，如消化不良、慢性胃炎、消化性溃疡和肠易激综合征；偏头痛、丛集性头痛、三叉神经痛或心律失常：
• US5391549A
  申请人：——

  公开号：US5391549A

  公开（公告）日：1995-02-21
• US5556851A
  申请人：——

  公开号：US5556851A

  公开（公告）日：1996-09-17