4-Methyl-1,6-naphthyridin | 7675-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Methyl-1,6-naphthyridin
• 英文别名: 4-Methyl-1,6-naphthyridine
• CAS: 7675-30-1
• 化学式: C₉H₈N₂
• 分子量: 144.176
• InChiKey: NVIRFBFIFVSTCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF
  申请人：Bennett Frank

  公开号：US20100322901A1

  公开（公告）日：2010-12-23

  The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

  本发明涉及公式（I）的5,6-环接合吲哚衍生物，包含至少一种5,6-环接合吲哚衍生物的组合物，以及利用这些5,6-环接合吲哚衍生物治疗或预防患者病毒感染或与病毒相关的疾病的方法。
• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET PROCÉDÉS D'UTILISATION
  申请人：INTEGRAL BIOSCIENCES PVT LTD

  公开号：WO2020012357A1

  公开（公告）日：2020-01-16

  The present invention discloses compounds useful in treatment of conditions associated with excessive activity of transforming growth factor beta (TGF-β), particularly type 1 or activin-like kinase 5 (ALK 5). Specifically the present invention discloses compound of formula (I) which exhibit inhibitory activity against ALK 5. Method of treating conditions associated with excessive activity (ALK 5) with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

  本发明揭示了在治疗与转化生长因子β（TGF-β）过度活性相关的疾病中有用的化合物，特别是针对类型1或类活化激酶5（ALK 5）。具体来说，本发明揭示了具有对ALK 5具有抑制活性的化合物的结构式（I）。还公开了使用这种化合物治疗与过度活性（ALK 5）相关的疾病的方法。此外，还公开了这些化合物的用途、制药组合物和试剂盒。
• [EN] HETEROCYCLIC INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS<br/>[FR] INHIBITEURS HÉTÉROCYCLIQUES DE TRANSPORTEURS DE MONOCARBOXYLATE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2016118825A1

  公开（公告）日：2016-07-28

  The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

  该发明提供了抑制单羧酸转运蛋白（如MCT1和MCT4）的化合物。该发明的化合物可用于治疗患者的某种疾病，其中该疾病的特征是MCT1和/或MCT4的活性增强或高度普遍，例如癌症或2型糖尿病。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20160285011A1

  公开（公告）日：2016-09-29

  An organic light-emitting device including a first electrode as an anode; a second electrode as a cathode and facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, a hole transport region between the first electrode and the emission layer, and an electron transport region between the emission layer and the second electrode, where at least one selected from the emission layer and the electron transport region includes at least one selected from condensed cyclic compounds represented by Formula 1: A 2 -(A 1 ) n1 .  Formula 1

  一种有机发光器件，包括第一电极作为阳极；第二电极作为阴极，且与第一电极相对；以及位于第一电极和第二电极之间的有机层，该有机层包括一个发射层，在第一电极和发射层之间的一个空穴传输区域，以及在发射层和第二电极之间的一个电子传输区域，其中发射层和电子传输区域中的至少一个包括由Formula 1：A2-(A1)n1表示的至少一个紧缩环化合物中的至少一个。
• CONDENSED CYCLIC COMPOUND AND AN ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20170194571A1

  公开（公告）日：2017-07-06

  A condensed cyclic compound represented by Formula 1 and an organic light-emitting device including the same.

  由式1表示的紧凑环状化合物以及包括该化合物的有机发光器件。