1H-pyrrolo[3,2-d]pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 1H-pyrrolo[3,2-d]pyrimidine-2,4-diamine
• 化学式: C₆H₇N₅
• 分子量: 149.15
• InChiKey: FQNHWGVMRAWNJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS<br/>[FR] COMPOSÉS ET COMPOSITIONS UTILES EN TANT QU'AGONISTES DU RÉCEPTEUR 7 DE TYPE TOLL
  申请人：NOVARTIS AG

  公开号：WO2015168279A1

  公开（公告）日：2015-11-05

  The invention provides compounds of formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

  该发明提供了公式（I）的化合物，包括这些化合物的免疫原组合物和药物组合物，以及使用这些化合物治疗与Toll样受体7活性相关的疾病或障碍的方法。
• NEW CLASSICAL ANTIFOLATES
  申请人：Chelsea Therapeutics, Inc.

  公开号：EP2125818A1

  公开（公告）日：2009-12-02
• COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS
  申请人：Novartis AG

  公开号：EP3137468A1

  公开（公告）日：2017-03-08
• SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES AS ANTIFOLATES
  申请人：Roberts Michael J.

  公开号：US20110152276A1

  公开（公告）日：2011-06-23

  The present invention is directed to antifolate compounds having the structure wherein: X is CHR 9 or NR 9 ; Y 1 , Y 2 , and Y 3 independently are O or S; V 1 and V 2 independently are O, S, or NZ; Z is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R 1 and R 2 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R 3 is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, hydroxyl, or halo; and R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, —C(O)-alkyl, —C(O)-alkenyl, or —C(O)-alkynyl; as well as pharmaceutically acceptable esters, amides, salts, solvates, and prodrugs thereof. The compounds are useful in pharmaceutical compositions and in methods of treating multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.
• US7951812B2
  申请人：——

  公开号：US7951812B2

  公开（公告）日：2011-05-31