2-Aethyl-thiophan-5.5-dioxyd | 10178-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 2-Aethyl-thiophan-5.5-dioxyd
• 英文别名: 2-Ethyl-tetramethylensulfon；2-Ethylsulfolan；2-Ethyltetrahydrothiophene 1,1-dioxide；2-ethylthiolane 1,1-dioxide
• CAS: 10178-59-3
• 化学式: C₆H₁₂O₂S
• 分子量: 148.226
• InChiKey: ZCDDAQJNJWLCLL-UHFFFAOYSA-N

物化性质

• 沸点：
  285.0±8.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环丁砜 、 溴乙烷 在 正丁基锂 作用下， 生成 2-Aethyl-thiophan-5.5-dioxyd
  参考文献：
  名称：

  Frazier, L.; Claypool, D. P., Synthetic Communications, 1988, vol. 18, # 6, p. 583 - 588

  摘要：

  DOI：

文献信息

• RAS INHIBITORS
  申请人：Revolution Medicines, Inc.

  公开号：US20210130369A1

  公开（公告）日：2021-05-06

  The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

  该披露涉及大环化合物，以及能够抑制Ras蛋白质的药物组合物和蛋白质复合物，以及它们在治疗癌症中的用途。
• [EN] INTEGRATED PROCESS FOR PRODUCING CYCLIC ACETALS AND OXYMETHYLENE POLYMERS<br/>[FR] PROCÉDÉ INTÉGRÉ DE PRODUCTION D'ACÉTALS CYCLIQUES ET DE POLYMÈRES D'OXYMÉTHYLÈNE
  申请人：TICONA GMBH

  公开号：WO2013076288A1

  公开（公告）日：2013-05-30

  A process for producing cyclic acetals is described. A formaldehyde source is contacted with an aprotic compound in the presence of a catalyst to produce the cyclic acetals. The aprotic compound can increase conversion rates and/or efficiency. In one embodiment, the formaldehyde source is obtained from methanol. In particular, methanol can be converted into formaldehyde which is then converted into a cyclic acetal. In one embodiment, the cyclic acetal can then be used to produce oxymethylene polymers.

  本文描述了一种制备环状缩醛的过程。在催化剂的存在下，将甲醛源与非质子溶剂化合物接触以产生环状缩醛。非质子溶剂可以提高转化率和/或效率。在一种实施方式中，甲醛源来自甲醇。特别地，甲醇可以转化为甲醛，然后再转化为环状缩醛。在一种实施方式中，环状缩醛可以用于制备氧甲基聚合物。
• [EN] PROCESS FOR PRODUCING A CYCLIC ACETAL IN A HETEROGENEOUS REACTION SYSTEM<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN ACÉTAL CYCLIQUE DANS UN SYSTÈME RÉACTIONNEL HÉTÉROGÈNE
  申请人：TICONA GMBH

  公开号：WO2013076290A1

  公开（公告）日：2013-05-30

  A process for producing a cyclic acetal is disclosed. According to the process, a formaldehyde source is combined with an aprotic compound and contacted with a heterogeneous catalyst which causes the formaldehyde source to convert into a cyclic acetal such as trioxane. The catalyst, for instance, may comprise a solid catalyst such as an ion exchange resin. In one embodiment, the process is used for converting anhydrous formaldehyde gas to trioxane. The anhydrous formaldehyde gas may be produced form an aqueous formaldehyde solution by an extractive distillation.

  本发明揭示了一种生产环状缩醛的工艺。根据该工艺，将甲醛源与无质子溶剂化合物结合，并与使甲醛源转化为环状缩醛的异相催化剂接触。例如，催化剂可以包括固体催化剂，如离子交换树脂。在一种实施例中，该工艺用于将无水甲醛气体转化为三聚氧杂环己烷。无水甲醛气体可以通过萃取蒸馏从水甲醛溶液中产生。
• Process for separating acid-containing gas mixtures
  申请人：Solvay SA

  公开号：EP2705893A1

  公开（公告）日：2014-03-12

  A process for reversibly removing at least one acid from a gas mixture comprising at least one acid and at least one of a carbonyl dihalide, a phosphoryl trihalide, a phosphorous pentafluoride, and an acid halide is provided. The process comprises contacting the gas mixture with a solvent comprising a sulphone compound.

  提供了一种用于可逆地从气体混合物中去除至少一种酸的过程，该气体混合物包括至少一种酸和至少一种羰基二卤化物、磷酰三卤化物、五氟化磷和酸卤化物之一。该过程包括将气体混合物与包含磺酰化合物的溶剂接触。
• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070099874A1

  公开（公告）日：2007-05-03

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及用于治疗由炎症反应引起的病理生理状态的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG（如Perlecan）来抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。