3-Vinyl-2,5-dihydrofuran | 1314888-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3-Vinyl-2,5-dihydrofuran
• 英文别名: 3-ethenyl-2,5-dihydrofuran
• CAS: 1314888-57-7
• 化学式: C₆H₈O
• 分子量: 96.1289
• InChiKey: YSOCGMWJYNDMPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  allyl propargyl ether 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以38%的产率得到3-Vinyl-2,5-dihydrofuran
  参考文献：
  名称：

  Ethylene-Promoted versus Ethylene-Free Enyne Metathesis

  摘要：

  The role of ethylene in promoting metathesis of acetylenic enynes is probed within the context of ring-closing enyne metathesis, using first- and second-generation Grubbs catalysts. Under inert atmosphere, rapid catalyst deactivation is observed by calibrated GC-FID analysis for substrates with minimal propargylic bulk. MALDI-TOF mass spectra reveal a Ru(enyne)(2) derivative that exhibits very low reactivity toward both enyne and ethylene. Under ethylene, formation of this species is suppressed. Enynes with bulky propargylic groups are not susceptible to this catalyst deactivation pathway, even under N-2 atmosphere.

  DOI：

  10.1021/ja207388v

文献信息

• Ethylene-Promoted versus Ethylene-Free Enyne Metathesis
  作者：Anne G. D. Grotevendt、Justin A. M. Lummiss、Melanie L. Mastronardi、Deryn E. Fogg

  DOI：10.1021/ja207388v

  日期：2011.10.12

  The role of ethylene in promoting metathesis of acetylenic enynes is probed within the context of ring-closing enyne metathesis, using first- and second-generation Grubbs catalysts. Under inert atmosphere, rapid catalyst deactivation is observed by calibrated GC-FID analysis for substrates with minimal propargylic bulk. MALDI-TOF mass spectra reveal a Ru(enyne)(2) derivative that exhibits very low reactivity toward both enyne and ethylene. Under ethylene, formation of this species is suppressed. Enynes with bulky propargylic groups are not susceptible to this catalyst deactivation pathway, even under N-2 atmosphere.