Piperazine, di-PFP

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: Piperazine, di-PFP
• 英文别名: 2,2,3,3,3-pentafluoro-1-[4-(2,2,3,3,3-pentafluoropropanoyl)piperazin-1-yl]propan-1-one
• 化学式: C₁₀H₈F₁₀N₂O₂
• 分子量: 378.17
• InChiKey: WQTVMEARTKHBJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  哌嗪 、 六氟环氧丙烷 以 苯 为溶剂， 反应 24.0h， 以90%的产率得到Piperazine, di-PFP
  参考文献：
  名称：

  Nucleophilic substitution reactions of heterocyclic amines and acyclic diamines with chlorofluoro olefins and hexafluoropropylene oxide

  摘要：

  The reactions of CH3N(H)CH2CH2N(H)CH3, CH3N(H)CH2CH2CH2N(H)CH3, and the cyclic amines piperazine, N-phenylpiperazine, and N-methylpiperazine with both cyclic and acyclic 1,2-dichloroperfluoroolefins are reported. Nucleophilic attack occurs at olefinic carbon, followed, in some cases, by cyclization and beta-elimination A variety of unusual polyfluorinated tertiary amines and heterocycles are synthesized.

  DOI：

  10.1021/jo00080a028

文献信息

• Mir Qui-Chee, Guo Cai-Yun, Kirchmeier Robert L., Shreeve Jeanne M., J. Org. Chem, 59 (1994) N 1, S 173-177
  作者：Mir Qui-Chee, Guo Cai-Yun, Kirchmeier Robert L., Shreeve Jeanne M.

  DOI：——

  日期：——
• Nucleophilic substitution reactions of heterocyclic amines and acyclic diamines with chlorofluoro olefins and hexafluoropropylene oxide
  作者：Qui Chee Mir、Cai Yun Guo、Robert L. Kirchmeier、Jean'ne M. Shreeve

  DOI：10.1021/jo00080a028

  日期：1994.1

  The reactions of CH3N(H)CH2CH2N(H)CH3, CH3N(H)CH2CH2CH2N(H)CH3, and the cyclic amines piperazine, N-phenylpiperazine, and N-methylpiperazine with both cyclic and acyclic 1,2-dichloroperfluoroolefins are reported. Nucleophilic attack occurs at olefinic carbon, followed, in some cases, by cyclization and beta-elimination A variety of unusual polyfluorinated tertiary amines and heterocycles are synthesized.