N-Benzoyl-N'-(benzothiazol-2-yl)-guanidin | 21926-88-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-Benzoyl-N'-(benzothiazol-2-yl)-guanidin
• 英文别名: Guanidine, 1-(2-benzothiazolyl)-2-benzoyl-；N-[(E)-N'-(1,3-benzothiazol-2-yl)carbamimidoyl]benzamide
• CAS: 21926-88-5
• 化学式: C₁₅H₁₂N₄OS
• mdl: MFCD01171438
• 分子量: 296.352
• InChiKey: FDGAEUMQPPIKDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
  申请人：Lindquist Susan L.

  公开号：US20080261953A1

  公开（公告）日：2008-10-23

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是疾病症状或病因的疾病中的一个或多个症状。在一种实施例中，用于组合物和方法的化合物是杂环基酰基胍、杂环基腙、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY
  申请人：WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

  公开号：EP1802303B1

  公开（公告）日：2011-11-02
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100004277A1

  公开（公告）日：2010-01-07

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for identification of compounds that rescue protein trafficking defects and methods of enhancing protein production.
• US8440705B2
  申请人：——

  公开号：US8440705B2

  公开（公告）日：2013-05-14
• [EN] COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING<br/>[FR] COMPOSÉS ET PROCÉDÉS DE MODULATION DU TRAFIC DE PROTÉINES
  申请人：FOLDRX PHARMACEUTICALS INC

  公开号：WO2007089548A2

  公开（公告）日：2007-08-09

  [EN] Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for identification of compounds that rescue protein trafficking defects and methods of enhancing protein production.
  [FR] La présente invention concerne des compositions et des procédés de modulation du trafic de protéines et le traitement ou la prévention de troubles caractérisés par un trafic de protéines altéré. L'invention concerne également des procédés d'identification de composés qui corrigent les défauts du trafic de protéines ainsi que des procédés d'amélioration de la production de protéines.