(6R)-2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: (6R)-2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
• 化学式: C₉H₁₅N₅O₃
• 分子量: 241.25
• InChiKey: FNKQXYHWGSIFBK-ZZVBZORRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  132
• 氢给体数：
  6
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-amino-6-[(2S)-1,2-dihydroxypropyl]-3H-pteridin-4-one 生成 (6R)-2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
  参考文献：
  名称：

  UTINO, XAYASI;ADZUMA, MASAAKI;OXASI, TAKEHXISA;VATANABEH, KIESI

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING CARBON-DIMINISHED ALDOSE COMPOUND
  申请人：Asubio Pharma Co., Ltd.

  公开号：EP1849793A1

  公开（公告）日：2007-10-31

  The present invention provides a process capable of industrially producing 5-deoxy-L-arabinose, important as a raw material for the production of sapropterin useful as a therapeutic agent for atypical hyperphenylalaninemia, satisfactorily efficiently even with a simple production apparatus. Provided is the process for producing 5-deoxy-L-arabinose characterized by including: reacting L-rhamnose with a C11-16 straight chain alkyl mercaptan compound in the presence of an acid catalyst to prepare L-rhamnose dialkylmercaptal; subjecting then the obtained compound to an oxidation reaction to prepare a sulfonyl derivative; and subjecting then the sulfonyl derivative to a carbon-reduction reaction to prepare 5-deoxy-L-arabinose. The present production process can also be applied to a process for producing compounds obtained by removing one carbon atom from other aldol compounds, and thus the present invention provides a general process for producing compounds obtained by reducing the number of carbon atoms from aldose compounds.

  本发明提供了一种工业生产5-去氧-L-阿拉伯糖的方法，该方法是生产治疗非典型高苯丙氨酸血症的治疗剂Sapropterin的原材料，即使使用简单的生产设备也能高效地生产。该生产方法包括以下步骤：在酸催化剂的存在下，将L-鼠李糖与C11-16直链烷基巯基化合物反应，制备L-鼠李糖二烷基硫代缩醛；然后将所得化合物进行氧化反应，制备磺酰基衍生物；最后将磺酰基衍生物进行碳还原反应，制备5-去氧-L-阿拉伯糖。该生产方法也可以应用于从其他醛糖化合物中去除一个碳原子得到的化合物的生产过程，因此本发明提供了一种从醛糖化合物中减少碳原子数量得到化合物的通用生产方法。
• Use of Tetrahydrobiopterine Derivatives in the Treatment and Nutrition of Patients With Amino Acid Metabolic Disorders
  申请人：BioMarin Pharmaceutical Inc.

  公开号：US20170042899A1

  公开（公告）日：2017-02-16

  The invention relates to the use of tetrahydrobiopterine and the derivatives thereof in the production of a medicament to improve protein tolerance for the treatment of diseases arising from an amino acid metabolic disorder, e.g. hyperphenylalaninemia. The invention also relates to a composition which contains tetrahydrobiopterine or derivatives thereof in addition to a special mixture of amino acids. The invention can, for instance, be used as a food which is low in phenylalanine in the complete nutrition of hyperphenylalaninemic patients. Tests carried out within the text of said invention revealed that by treating the context of said invention revealed that by treating patients who had phenylalanine concentrations of more than 200 μmol/l in their blood with tetrahydrobiopterine, it was possible to reduce the concentrations of phenylalanine by 37% to 92%.
• UTINO, XAYASI;ADZUMA, MASAAKI;OXASI, TAKEHXISA;VATANABEH, KIESI
  作者：UTINO, XAYASI、ADZUMA, MASAAKI、OXASI, TAKEHXISA、VATANABEH, KIESI

  DOI：——

  日期：——