6-Amino-4-(4-hydroxy-3,5-dimethoxyphenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | 664999-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 6-Amino-4-(4-hydroxy-3,5-dimethoxyphenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• CAS: 664999-80-8
• 化学式: C₁₇H₁₈N₄O₅
• 分子量: 358.3
• InChiKey: ATWYJCVVIYNUNA-UHFFFAOYSA-N

物化性质

• 沸点：
  620.9±55.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)
• 溶解度：
  20.6 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification
  申请人：Burnham Institute for Medical Research

  公开号：EP2433496A1

  公开（公告）日：2012-03-28

  Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.

  本文公开的化合物是组织非特异性碱性磷酸酶抑制剂。所公开的化合物可用于治疗、预防或减轻血管钙化、动脉钙化和其他心血管疾病。
• TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION
  申请人：MILLAN JOSE LUIS

  公开号：US20090156560A1

  公开（公告）日：2009-06-18

  Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.
• US8119693B2
  申请人：——

  公开号：US8119693B2

  公开（公告）日：2012-02-21
• [EN] TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION<br/>[FR] INHIBITEURS DE LA PHOSPHATASE ALCALINE NON SPÉCIFIQUES À UN TISSU ET LEURS UTILISATIONS POUR TRAITER UNE CALCIFICATION VASCULAIRE
  申请人：BURNHAM INST MEDICAL RESEARCH

  公开号：WO2009017863A2

  公开（公告）日：2009-02-05

  Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.