(E)-N,N'-[2,2'-(ethene-1,2-diyl)bis(4-fluoro-2,1-phenylene)]dibenzenesulfonamide | 1361391-51-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-N,N'-[2,2'-(ethene-1,2-diyl)bis(4-fluoro-2,1-phenylene)]dibenzenesulfonamide
• 英文别名: N-[2-[(E)-2-[2-(benzenesulfonamido)-5-fluorophenyl]ethenyl]-4-fluorophenyl]benzenesulfonamide
• CAS: 1361391-51-6
• 化学式: C₂₆H₂₀F₂N₂O₄S₂
• 分子量: 526.585
• InChiKey: GADDCTZYUQNGGN-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (E)-N,N'-[2,2'-(ethene-1,2-diyl)bis(4-fluoro-2,1-phenylene)]dibenzenesulfonamide 在 碘苯二乙酸 、 四丁基氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以84%的产率得到3,8-difluoro-5,10-bis(phenylsulfonyl)-4b,5,9b,10-tetrahydroindolo[3,2-b]indole
  参考文献：
  名称：

  Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal-Free Conditions

  摘要：

  A metal-free procedure that is simple to operate and convenient to handle was developed for the facile intramolecular oxidative diamination of olefins using an iodobenzene diacetate oxidant and a halide additive to furnish bisindolines at room temperature. The present reaction is featured by mild conditions, a broad substrate scope, and excellent functional group tolerance. The same protocol was successfully extended to the aminohydroxylation.

  DOI：

  10.1021/ol300166q
• 作为产物：
  描述：

  2-溴-4-氟苯胺 在 四(三苯基膦)钯 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 16.0h， 生成 (E)-N,N'-[2,2'-(ethene-1,2-diyl)bis(4-fluoro-2,1-phenylene)]dibenzenesulfonamide
  参考文献：
  名称：

  Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal-Free Conditions

  摘要：

  A metal-free procedure that is simple to operate and convenient to handle was developed for the facile intramolecular oxidative diamination of olefins using an iodobenzene diacetate oxidant and a halide additive to furnish bisindolines at room temperature. The present reaction is featured by mild conditions, a broad substrate scope, and excellent functional group tolerance. The same protocol was successfully extended to the aminohydroxylation.

  DOI：

  10.1021/ol300166q

文献信息

• Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal-Free Conditions
  作者：Hyun Jin Kim、Seung Hwan Cho、Sukbok Chang

  DOI：10.1021/ol300166q

  日期：2012.3.16

  A metal-free procedure that is simple to operate and convenient to handle was developed for the facile intramolecular oxidative diamination of olefins using an iodobenzene diacetate oxidant and a halide additive to furnish bisindolines at room temperature. The present reaction is featured by mild conditions, a broad substrate scope, and excellent functional group tolerance. The same protocol was successfully extended to the aminohydroxylation.