Cambridge id 5320380

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: Cambridge id 5320380
• 英文别名: 5-amino-2-(5-amino-1,3-benzothiazol-2-yl)phenol
• 化学式: C₁₃H₁₁N₃OS
• 分子量: 257.31
• InChiKey: SPFRVVBVZFZERU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Cyclohexyl derivatives and their use as therapeutic agents
  申请人：——

  公开号：US20030225059A1

  公开（公告）日：2003-12-04

  The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 13 , R 14 , R 15 , R 16 , R?17, R 18 , R 19 , R 21a and R 21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia. 1 2

  本发明涉及以下式(I)的化合物：其中环A是苯环或吡啶环；X代表从以下组中选择的连接基：(a)、(b)、(c)、(d)、(e)、(f)、(g)、(h)、(i)、(j)、(k)、(l)和R，R1、R2、R3、R4、R5、R6、R7、R13、R14、R15、R16、R?17、R18、R19、R21a和R21b如本文所定义。这些化合物在治疗或预防抑郁症、焦虑、疼痛、炎症、偏头痛、呕吐或带状疱疹后神经痛方面特别有用。
• POLYIMIDE FIBER AND PREPARATION METHOD THEREFOR
  申请人：Changchun Institute Of Applied Chemistry Chinese Academy Of Sciences

  公开号：EP3378976A1

  公开（公告）日：2018-09-26

  This application provides a polyimide fiber and a preparation method thereof. This method comprises first subjecting a dianhydride compound and a diamine compound to a polymerization reaction in a solvent to obtain a polyamic acid solution, wherein said diamine compound comprises a diamine having a structure of Formula 12 or Formula 13, wherein A is S or O; said dianhydride compound comprises one or more of dianhydrides having structures of Formula 14 and Formula 15; and t is 0 or 1; then subjecting said polyamic acid solution to spinning to obtain a polyamic acid fiber; and sequentially subjecting said polyamic acid fiber to imidization and thermal drawing to obtain a polyimide fiber. The polyimide fiber having the above structure has a higher rigidity and can introduce a hydrogen bond to provide an interaction between molecular chains so as to influence the arrangement of the molecular chain in the polymer and the crystallinity, which imparts more excellent mechanical properties to the polyimide fiber. The polyimide fiber obtained has a higher glass transition temperature (Tg) and a better heat resistance.

  本申请提供了一种聚酰亚胺纤维及其制备方法。该方法包括首先将二酐化合物和二胺化合物在溶剂中进行聚合反应以获得聚酰胺酸溶液，其中所述二胺化合物包括具有式 12 或式 13 结构的二胺，其中 A 为 S 或 O；所述二酐化合物包括具有式 14 和式 15 结构的一种或多种二酐；以及 t 为 0 或 1；然后将所述聚酰胺酸溶液进行纺丝，以获得聚酰胺酸纤维；并依次将所述聚酰胺酸纤维进行酰亚胺化和热拉伸，以获得聚酰亚胺纤维。具有上述结构的聚酰亚胺纤维具有更高的刚性，并能引入氢键，提供分子链之间的相互作用，从而影响聚合物中分子链的排列和结晶度，使聚酰亚胺纤维具有更优异的机械性能。得到的聚酰亚胺纤维具有更高的玻璃化温度（Tg）和更好的耐热性。
• Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein
  申请人：Kudo Yukitsuka

  公开号：US20050260126A1

  公开（公告）日：2005-11-24

  A compound, which is used for the diagnosis and the prophylaxis/treatment of diseases in which prion protein is accumulated, or specific staining of abnormal prion protein in samples, represented by the formula (I) or (II): or a salt or solvate thereof.

  一种化合物，用于诊断和预防/治疗朊病毒蛋白蓄积的疾病，或特异性染色样本中的异常朊病毒蛋白，由式（I）或（II）表示： 或其盐或溶解物。
• POLYMIDE FIBER AND PREPARATION METHOD THEREOF
  申请人：CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

  公开号：US20180282907A1

  公开（公告）日：2018-10-04

  This application provides a polyimide fiber and a preparation method thereof. This method comprises first subjecting a dianhydride compound and a diamine compound to a polymerization reaction in a solvent to obtain a polyamic acid solution, wherein said diamine compound comprises a diamine having a structure of Formula 12 or Formula 13, wherein A is S or O; said dianhydride compound comprises one or more of dianhydrides having structures of Formula 14 and Formula 15; and t is 0 or 1; then subjecting said polyamic acid solution to spinning to obtain a polyamic acid fiber; and sequentially subjecting said polyamic acid fiber to imidization and thermal drawing to obtain a polyimide fiber. The polyimide fiber having the above structure has a higher rigidity and can introduce a hydrogen bond to provide an interaction between molecular chains so as to influence the arrangement of the molecular chain in the polymer and the crystallinity, which imparts more excellent mechanical properties to the polyimide fiber. The polyimide fiber obtained has a higher glass transition temperature (Tg) and a better heat resistance.
• US6953792B2
  申请人：——

  公开号：US6953792B2

  公开（公告）日：2005-10-11