2-Phenylamino-octan-1-ol | 99930-78-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Phenylamino-octan-1-ol
• 英文别名: 2-Anilinooctan-1-ol
• CAS: 99930-78-6
• 化学式: C₁₄H₂₃NO
• 分子量: 221.343
• InChiKey: OMKHZUASSOJOKL-UHFFFAOYSA-N

物化性质

• 沸点：
  362.6±15.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯胺 、 1,2-环氧辛烷 在 zeolite 作用下， 以 苯 为溶剂， 反应 9.0h， 生成 N-phenyl-1-amino-2-octanol 、 2-Phenylamino-octan-1-ol
  参考文献：
  名称：

  ZEOLITE-CATALYZED RING-OPENING OF EPOXIDES WITH AMINES

  摘要：

  不对称环氧化物与胺的开环反应已采用沸石作为催化剂进行研究。中等酸性和碱性的沸石相比强酸性或强碱性的沸石表现出更高的催化活性和区位选择性。沸石中酸性和碱性位点的协同作用被认为对有效催化是必不可少的。

  DOI：

  10.1246/cl.1985.779

文献信息

• Zr(DS)₄ as an Efficient Catalyst for the Aminolysis of Epoxides in Water
  作者：Francesco Fringuelli、Luigi Vaccaro、Simona Bonollo、Ferdinando Pizzo

  DOI：10.1055/s-2007-991075

  日期：——

  Zirconium dodecyl sulfate [Zr(DS) 4 ] is an efficient catalyst for the aminolysis of epoxides in water at pH 5.0. Epoxides and anilines were used and the corresponding β-amino alcohols were isolated in generally high regioselectivity and excellent yields.

  十二烷基硫酸锆 [Zr(DS) 4 ] 是一种有效的催化剂，用于在 pH 5.0 的水中氨解环氧化物。使用环氧化物和苯胺，并以通常高的区域选择性和优异的产率分离出相应的 β-氨基醇。
• A solvent free method for preparation of β-amino alcohols by ring opening of epoxides with amines using MCM-22 as a catalyst
  作者：Thangaraj Baskaran、Akanksha Joshi、Gunda Kamalakar、Ayyamperumal Sakthivel

  DOI：10.1016/j.apcata.2016.05.029

  日期：2016.8

  β-amino alcohols were synthesized at room temperature employing microporous MCM-22 zeolite as catalyst in an eco-friendly manner without using solvent. The zeolite MCM-22 showed promising activity for the conversion of primary and secondary amines into β-amino alcohols under mild reaction conditions. The catalytic activity remains intact for three recycles.

  在室温下以微孔MCM-22沸石为催化剂以环保方式合成β-氨基醇，无需使用溶剂。MCM-22沸石在温和的反应条件下，具有将伯胺和仲胺转化为β-氨基醇的活性。在三个循环中，催化活性保持不变。
• Hβ zeolite: An Efficient and Reusable Catalyst for Ring-Opening of Epoxides with Amines Under Microwave Irradiation
  作者：Rukhsana I. Kureshy、Santosh Agrawal、Manish Kumar、Noor-ul H. Khan、Sayed H. R. Abdi、Hari C. Bajaj

  DOI：10.1007/s10562-009-0237-z

  日期：2010.2

  A solvent-free protocol for the synthesis of beta-amino alcohols (Yield, up to 94%) is demonstrated by the ring-opening reactions of meso and terminal epoxides with aromatic amines using H beta zeolite as catalyst under microwave irradiation. The catalytic system is 80 times faster than the reaction conducted at RT with six times catalyst recyclability.
• Potassium Dodecatungstocobaltate Trihydrate (K₅CoW₁₂O₄₀ · 3H₂O) as an Efficient Catalyst for Aminolysis of Epoxides
  作者：E. Rafiee、Shahram Tangestaninejad、M. H. Habibi、V. Mirkhani

  DOI：10.1081/scc-200032411

  日期：2004.1.1

  Aminolysis of epoxides using various amines was catalyzed with potassium dodecatungstocobaltate trihydrate in a convenient and efficient method with good selectivities.