3,3-Bis(diethoxyphosphoryl)propoxybenzene | 108816-75-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 3,3-Bis(diethoxyphosphoryl)propoxybenzene
• CAS: 108816-75-7
• 化学式: C₁₇H₃₀O₇P₂
• 分子量: 408.369
• InChiKey: GHDCMYVFZRDYIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,3-Bis(diethoxyphosphoryl)propoxybenzene 在 盐酸 作用下， 反应 19.0h， 生成 3,3-Bis(dimethoxyphosphoryl)propoxybenzene
  参考文献：
  名称：

  gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity

  摘要：

  New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of numerous compounds has permitted the determination of the structural variations leading to optimal plasma lipid altering activity, indicating antiatherosclerotic potential. Among the compounds observed to be the most active, dimethyl alpha-(dimethoxyphosphinyl)-p-chlorobenzyl phosphate (20, SR-202, mifobate) was selected for further pharmacological and subsequent clinical development.

  DOI：

  10.1021/jm00391a027
• 作为产物：
  描述：

  亚甲基二磷酸四乙酯 、 2-苯氧乙基溴 在 sodium hydride 作用下， 生成 3,3-Bis(diethoxyphosphoryl)propoxybenzene
  参考文献：
  名称：

  gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity

  摘要：

  New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of numerous compounds has permitted the determination of the structural variations leading to optimal plasma lipid altering activity, indicating antiatherosclerotic potential. Among the compounds observed to be the most active, dimethyl alpha-(dimethoxyphosphinyl)-p-chlorobenzyl phosphate (20, SR-202, mifobate) was selected for further pharmacological and subsequent clinical development.

  DOI：

  10.1021/jm00391a027

文献信息

• Highly selective α-aryloxyalkyl C–H functionalisation of aryl alkyl ethers
  作者：Jonathan D. Bell、Iain Robb、John A. Murphy

  DOI：10.1039/d2sc04463c

  日期：——

  We report highly selective photocatalytic functionalisations of alkyl groups in aryl alkyl ethers with a range of electron-poor alkenes using an acridinium catalyst with a phosphate base and irradiation with visible light (456 nm or 390 nm). Experiments indicate that the reaction operates via direct single-electron oxidation of the arene substrate ArOCHRR′ to its radical cation by the excited state

  我们报告了使用具有磷酸盐基的吖啶催化剂和可见光（456 nm 或 390 nm）辐照，对芳基烷基醚中的烷基与一系列缺电子烯烃进行高选择性光催化官能化。实验表明该反应通过通过激发态有机光催化剂将芳烃底物ArOCHRR'直接单电子氧化为其自由基阳离子；随后，自由基阳离子中的 ArOC–H 去质子化，产生自由基 ArOC˙RR'。然后该自由基攻击亲电子试剂形成中间烷基自由基，该烷基自由基被还原以完成光催化循环。氧化步骤对活性芳烃 (ArOR) 的选择性超过其非活性对应物，随后甲氧基的去质子化提供 α-芳氧基烷基自由基，从而以良好到极好的收率产生范围广泛的功能化产品。
• NGUYEN, LAN M.;NIESOR, ERIC;BENTZEN, CRAIG L., J. MED. CHEM., 30,(1987) N 8, 1426-1433
  作者：NGUYEN, LAN M.、NIESOR, ERIC、BENTZEN, CRAIG L.

  DOI：——

  日期：——
• gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity
  作者：Nguyen Lan Mong、Eric Niesor、Craig L. Bentzen

  DOI：10.1021/jm00391a027

  日期：1987.8

  New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of numerous compounds has permitted the determination of the structural variations leading to optimal plasma lipid altering activity, indicating antiatherosclerotic potential. Among the compounds observed to be the most active, dimethyl alpha-(dimethoxyphosphinyl)-p-chlorobenzyl phosphate (20, SR-202, mifobate) was selected for further pharmacological and subsequent clinical development.