2-(2-(thienylmethyl)amino)-2-methylpropanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2-(thienylmethyl)amino)-2-methylpropanol
• 英文别名: 2-Methyl-2-[(thiophen-2-ylmethyl)amino]propan-1-ol；2-methyl-2-(thiophen-2-ylmethylamino)propan-1-ol
• 化学式: C₉H₁₅NOS
• mdl: MFCD03863982
• 分子量: 185.29
• InChiKey: OIHHTDRRPSXECH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  60.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methyl-2-(thiophen-2-ylmethylideneamino)propan-1-ol 在 sodium tetrahydroborate 作用下， 生成 2-(2-(thienylmethyl)amino)-2-methylpropanol
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

  摘要：

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

  DOI：

  10.1111/j.1747-0285.2011.01231.x

文献信息

• A New Approach to the Synthesis of<i>N</i>-Arylakyl Aminoalcohols
  作者：V. Leskovšek、U. Urleb

  DOI：10.1080/00397919408011745

  日期：1994.5

  N-arylmethyl substituted aminoalcohols were prepared by enantioseletive reductive amination of different aromatic and heteroaromatic aldehydes using aminoalcohols and NaBH3CN as a catalyst. The reaction of optically active aminoalcohols afforded optically pure products.