N-(5-chloro-2-methylphenyl)-2-(4-oxo-3(4H)-quinazolinyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(5-chloro-2-methylphenyl)-2-(4-oxo-3(4H)-quinazolinyl)acetamide
• 英文别名: N-(5-chloro-2-methylphenyl)-2-(4-oxoquinazolin-3-yl)acetamide
• 化学式: C₁₇H₁₄ClN₃O₂
• 分子量: 327.8
• InChiKey: FASMCYVDXFNBJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF CYCLIC MONO- AND DI-NUCLEOTIDE PHOSPHODIESTERASES AND THE USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20220194957A1

  公开（公告）日：2022-06-23

  Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.