3-Hydroxy-4-methoxymandelate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-Hydroxy-4-methoxymandelate
• 英文别名: (2R)-2-hydroxy-2-(3-hydroxy-4-methoxyphenyl)acetic acid
• 化学式: C₉H₁₀O₅
• 分子量: 198.17
• InChiKey: PXMUSCHKJYFZFD-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method and product for skin lightening
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20030044362A1

  公开（公告）日：2003-03-06

  A method and cosmetic product for lightening skin is provided, the method including wiping the skin with a cosmetic towelette. Impregnated on the towelette is an alpha-hydroxy carboxylic acid or salt thereof and a sunscreen agent.

  提供一种用于美白皮肤的方法和化妆品产品，该方法包括用化妆湿巾擦拭皮肤。湿巾上浸渍有α-羟基羧酸或其盐以及防晒剂。
• [EN] COMPOSITIONS AND METHODS FOR PARASITE CONTROL<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE LUTTE CONTRE LES PARASITES
  申请人：PHILIP MORRIS PRODUCTS SA

  公开号：WO2021260029A1

  公开（公告）日：2021-12-30

  The present invention relates in its broadest aspect to a compound of Formula I as provided herein, formulations comprising such a compound and corresponding uses thereof for the reduction of infestation with ectoparasites, in particular ectoparasites of the insect class, including fleas and mosquitoes and/or ectoparasites of the arachnid class, including ticks and mites, etc. Also provided herein are methods for preparing the formulations of the invention and methods for controlling ectoparasites using the compounds and/or formulations provided herein.

  本发明最广泛地涉及一种公式I的化合物，以及包含该化合物的制剂及其相应用途，用于减少外寄生虫的感染，特别是昆虫类的外寄生虫，包括跳蚤和蚊子，以及蜘蛛类的外寄生虫，包括蜱和螨等。本文还提供了制备本发明制剂的方法以及使用本文所提供的化合物和/或制剂控制外寄生虫的方法。
• HYDROXYMONOCARBOXYLIC ACID-BASED MAILLARD BINDER
  申请人：KNAUF INSULATION, LLC

  公开号：US20150183959A1

  公开（公告）日：2015-07-02

  Binders to produce or promote cohesion in non-assembled or loosely assembled matter.

  Binders旨在生产或促进非组装或松散组装的物质中的凝聚。
• Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots.
  申请人：Van Scott, Eugene J., Dr.

  公开号：EP0273202A2

  公开（公告）日：1988-07-06

  Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic compostion has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

  本发明公开了增强外用药剂治疗效果的组合物和方法。该化妆品或治疗组合物可包括一种或多种化妆品或药物制剂，其总量为组合物总重量的 0.01% 至 40%，以及一种或多种羟基羧酸或相关化合物，其总量为组合物总重量的 0.01% 至 99%。化妆品和药物制剂可包括但不限于老年斑、皱纹和角化去除剂；维生素；芦荟；防晒霜；美黑、脱色和洗发剂；抗酵母菌；抗真菌、抗细菌和抗病毒剂；局部支气管扩张剂和局部心血管制剂；激素制剂；血管扩张剂；维甲酸和其他皮肤病制剂。羟基羧酸及相关化合物包括有机 alpha 和 beta 羟基羧酸、alpha 和 beta 酮羧酸及其盐类。研究发现，局部施用美容或治疗复合剂可大幅提高活性成分对人类和驯养动物的美容或治疗效果。
• Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
  申请人：Yu, Ruey J., Dr.

  公开号：EP0413528A1

  公开（公告）日：1991-02-20

  Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

  本发明公开了含有α-羟基酸、α-酮酸、相关化合物或羟基酸聚合形式的两性组合物的预防和治疗方法，以缓解美容状况和皮肤病症状。两性组合物和聚合化合物可用于治疗的美容病症和皮肤病包括皮肤干燥、头皮屑、痤疮、角化病、牛皮癣、湿疹、瘙痒症、老年斑、色斑、黑斑、皱纹、疣、瑕疵皮肤、色素沉着皮肤、角化过度皮肤、炎症性皮肤病、与衰老有关的皮肤变化以及需要清洁剂的皮肤。