6-Methoxy-3-(4-methoxyphenyl)-2,4-dihydro-1,3-benzoxazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 6-Methoxy-3-(4-methoxyphenyl)-2,4-dihydro-1,3-benzoxazine
• 化学式: C₁₆H₁₇NO₃
• mdl: MFCD02233774
• 分子量: 271.31
• InChiKey: FZGXSMPDJWGEPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE MODULATION DE LA FERROPTOSE ET DE TRAITEMENT DE TROUBLES EXCITOTOXIQUES
  申请人：UNIV COLUMBIA

  公开号：WO2020113028A1

  公开（公告）日：2020-06-04

  The present disclosure provides, inter alia, a compound having the structure (1). Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject.

  本公开提供一种具有结构（1）的化合物。还提供了含有药用可接受载体和根据本公开披露的一个或多个化合物的组合物。此外，还提供了治疗或改善受体内兴奋毒性紊乱影响的方法，调节受体内铁死亡的方法，减少细胞内活性氧（ROS）的方法，治疗或改善神经退行性疾病影响的方法，缓解正在接受放射治疗和/或免疫治疗的受体的副作用的方法，以及治疗或改善与受体内铁死亡相关的感染影响的方法。
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR USE IN TREATING AUTOPHAGY-ASSOCIATED DISORDERS
  申请人：Biophagy, Inc.

  公开号：US20200190007A1

  公开（公告）日：2020-06-18

  The invention provides compounds and methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits.

  本发明提供了化合物及其治疗自噬介导的疾病和障碍的方法，以及相关的药物组合物、诊断、筛选技术和试剂盒。
• Compounds, compositions, and methods for use in treating autophagy-associated disorders
  申请人：Biophagy, Inc.

  公开号：US11208371B2

  公开（公告）日：2021-12-28

  The invention provides compounds and methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits.

  本发明提供了治疗自噬介导的疾病和失调的化合物和方法，以及相关的药物组合物、诊断方法、筛选技术和试剂盒。
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210299107A1

  公开（公告）日：2021-09-30

  The present disclosure provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject.
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR USE IN TREATING AUTOPHAGY-ASSOCIATED DISORDERS<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE TROUBLES ASSOCIÉS À L'AUTOPHAGIE
  申请人：BIOPHAGY INC

  公开号：WO2020131924A1

  公开（公告）日：2020-06-25

  The invention provides compounds and methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits.